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Post-operative fibrosis of trabulectomy blebs is a major cause of surgical failure leading to a renewed increase in intraocular pressure. The use of anti-metabolites over many years has made it possible to improve success rates for this surgery but these drugs have numerous adverse effects as they are toxic. Alternative therapies are thus necessary, and we believe that DHA could have antifibrotic effects on fibroblasts and could thus improve success rates in this surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases | Glaucoma surgery |
| |
| Controls | Strabismus surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Samples of fibroblasts from Tenon's capsule | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Test of cell viability by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) | At baseline | |
| Test migration ability by video microscopy | At baseline | |
| Test proliferation with immunohistochemistry (Ki67 staining) | At baseline | |
| Analysis of cell cycle in flow cytometry | At baseline |
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Inclusion Criteria:
Exclusion Criteria:
- Patients who refuse to take part in the study
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Patients undergoing surgery for glaucoma or strabismus
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alain BRON | Contact | 03 80 29 37 56 | +33 | alain.bron@chu-dijon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu Dijon Bourogne | Recruiting | Dijon | France |
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fibroblasts of Tenon's capsule (surgical waste)