NEUROFEEDBACK on Event-Related Potential (ERP)

Clinical Evaluation of a Brain Computer Interfaces (BCI)-Based Training of Attention in Children With Attention Deficit Hyperactivity Disorder (ADHD)

This project aims to assess the evolution of symptoms in ADHD children from 8 to 17 years, with various types of attention training.

Different groups A, B and C will be evaluated: the first with Neurofeedback training, the second with a similar training but not indexed on brain activity and the third without training.

30 patients will be randomly assigned to groups A and B according to a ratio 2:1.

Others patients who meet the same criteria but for logistical reasons cannot comply with the training constraints will be assigned to group C.

Children included in groups A and B will participate in training sessions (Neurofeedback and control training, respectively) as well as in four evaluation sessions. Children in group C will only participate in evaluation sessions (baseline control group).

Patients of groups A and B will be followed over 6 months: 4 months of training and a follow-up evaluation 2 months after training.

Patients of group C will be followed each 2 months for 6 months. This study uses electro-encephalography measures, serious video game, neuropsychological tests and questionnaires.

It also uses actigraphy measures to evaluate sleep quality.

Inclusion Criteria:

• Children and teenagers aged from 8 to 17 years' old
• Children and teenagers with a deficit attention disorder with or without hyperactivity, in the mixed form or in a pure inattentive form according to Diagnostique et Statistique des troubles Mentaux (DSM)-V.
• Children and teenagers having a score in Verbal Comprehension Index (or Index Verbal Reasoning) and Perceptual Reasoning Index (or Index Reasoning fluid) ≥ 80 of WISC IV or V test, not older than two years.
• Children and teenagers without psychostimulant treatment
• Children and teenagers with psychostimulant treatment agreed to achieve a therapeutic break at each visit day and with a stable dose during all the study.
• Children and teenagers whose parents have agreed and signed informed consent form of the study.

Exclusion Criteria:

• Children aged less than 8 and teenagers are more than 18 years' old.
• Children and teenagers having a score in Verbal Comprehension Index (or Index Verbal Reasoning) and Perceptual Reasoning Index (or Index Reasoning fluid) < 80 of WISC IV or V test, not older than two years.
• Children and teenagers with developmental disorder except "Dys" disorders.
• Children and teenagers with pure hyperactivity (without attentional deficit)
• Children and teenagers with epilepsy except benign epilepsies (without brain damage), free of crisis for two years and without treatment.
• Children and teenagers with ADHD with conduct disorders and aggression
• Children and teenagers with ADHD and Tourette's syndrome.
• Patients treated by anti / epilepsy or psychotropic treatments (with the exception of psychostimulant treatment).
• Patients with psychostimulant treatment and whose parents aren't agreed to achieve a therapeutic break at each visit day.
• Patients with visual deficiency uncorrectable with lenses or glasses.