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| Name | Class |
|---|---|
| Universiteit Antwerpen | OTHER |
| Centers for Disease Control and Prevention | FED |
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Despite the mass distribution of LLINs (long-lasting insecticidal nets) as a Malaria control strategy, populations are still continuously exposed to a high frequency of malarial inoculation in some countries. The situation can be explained by a swift increase in the resistance of Anopheles to common insecticides. To preserve the gains of insecticides and improve their effectiveness, a new generation of bednets treated with piperonyl butoxide combination insectides have emerged.But more evidence is needed to plead for scale up of their usage. The lack of information relating to the additional impact of that combination on the transmission of Malaria, its relative efficacy in real-life setting and its safety in users are the rationale for more investigation.This will be a randomized controlled study on a dynamic cohort of households with 1680, 0-10 years-old subjects in 30 villages will be recruited to compute the effectiveness of this new tool.
The findings will be useful information for decision-making by national malaria control programs, their partners, the international community and the bednet manufacturers with regard to the effectiveness of the new combination of insecticides in real-life context. The results will also enable a better design of the tool in the future and a broader understanding of long-term dynamics for sustainability, as well as identification of some factors with negative impacts on the benefits of the strategy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | The arm will receive bednets treated with conventional insecticide (Pyrethroid) |
|
| Experimental | Experimental | The arm will receive bednets treated with new generation of insecticides (synergistic combination of insecticides) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| synergistic combination of insecticides | Drug | third generation insecticide -treated bednets |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence rate of laboratory confirmed clinical cases of Malaria | Microscopy to confirm the diagnosis of Malaria | Participants will be actively followed up for 12 months. And any suspected case of clinical Malaria will immediately lead to microscopy and RDT for confirmation |
| Sporozoite rate | Sporozoite detection by ELISA to determine infectivity of anopheles | Anopheles mosquitoes will be captured every 3 months during 1 year |
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Inclusion Criteria : -households where there are one or more children below the age of 10 years;
Exclusion Criteria :
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Général de Référence Saint Luc | Kisantu | Bas-Congo Province | Democratic Republic of the Congo |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34027998 | Derived | Gleave K, Lissenden N, Chaplin M, Choi L, Ranson H. Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa. Cochrane Database Syst Rev. 2021 May 24;5(5):CD012776. doi: 10.1002/14651858.CD012776.pub3. |
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Cluster-randomized trial
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The 2 groups of villages will randomly receive either the bednets treated with conventional insecticide (Pyrethroid) or the synergistic combination of insecticides. None of the groups knows which bednets they receive.
| Pyrethroids | Drug | Conventional insecticide |
|
| ID | Term |
|---|---|
| D011722 | Pyrethrins |
| ID | Term |
|---|---|
| D000081004 | Cyclopentane Monoterpenes |
| D039821 | Monoterpenes |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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