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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A01543-50 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| General Electric | INDUSTRY |
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The purpose of this study is to accurately map calcaneal fibrocartilage using TE = 0 ms imaging, and then apply measurements of our control population to SpA patients with peripheral enthesis study using the calcaneal tendon as a clinical model
The human body contains a lot of tissue components with short T2 (transversal relaxation time) that are not or only poorly detected on conventional T2-weighted MR sequences. These components are mostly located in musculoskeletal organs such as tendons, ligaments, menisci, periosteum or cortical bone.
Considering that conventional sequences do not detect tissue components with T2 shorter than 10ms, imaging of body tendon or enthesis is therefore very limited. This represents a limitation of MR imaging in early diagnosis of a certain number of pathologies, such as mechanical or mostly inflammatory tendinopathy or enthesopathy.
This study, would provide the feasibility of ZTE 2 sequence to quantitatively assess normal and pathological spondyloarthropathy Achilles tendon enthesis at 3 T, and would demonstrate that this sequence allows the detection of SpA enthesopathy prior to conventional sequences and enables disease monitoring.
For those purposes, during inclusion visit sequences ZTE 2 and UTE (with and without gadolinium injection) will be add to routine macrocyclic gadolinium injected MRI of 3 groups of patients (symptomatic and non sympatomatic spondyloarthropathy and mechanical tendinopathy). Healthy volunteer group will undergo an MRI exam without gadolinium injection comprised of following sequences T2 FS, T1, DP FS, ZTE 2 and UTE.
No follow up visit are schedule in this study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HEALTHY VOLUNTEERS | Experimental |
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| SPA + NON-SYMPTOMATICS | Experimental |
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| SPA + SYMPTOMATICS | Experimental |
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| MECHANIC TENDINOPATHY | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI ZTE2 sequence | Device | feasibility of ZTE 2 sequence to quantitatively assess normal and pathological spondyloarthropathy |
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| Measure | Description | Time Frame |
|---|---|---|
| Maximum ZTE signal value in healthy volunteers | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum difference of the ZTE signal value between healthy volunteers and non-symptomatic SpA + patients in the calcaneal fibrocartilage | baseline | |
| Maximum difference of the ZTE signal value between healthy volunteers and symptomatic SpA + patients in the calcaneal fibrocartilage |
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Inclusion Criteria:
Additional criteria for each group:
GROUP 1: HEALTHY VOLUNTEERS
GROUP 2: SPA + NON-SYMPTOMATICS AT THE CALCANEEN FIBROCARTILAGE LEVEL
GROUP 3: SPA + SYMPTOMATICS AT THE CALCANEEN FIBROCARTILAGE LEVEL
GROUP 4: MECHANIC TENDINOPATHY
Exclusion Criteria:
Additional criteria for GROUPS 2, 3 and 4:
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| Name | Affiliation | Role |
|---|---|---|
| Olivier Hauger, MD, Ph.D | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux | Bordeaux | 33076 | France |
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| ID | Term |
|---|---|
| D025242 | Spondylarthropathies |
| D052256 | Tendinopathy |
| ID | Term |
|---|---|
| D025241 | Spondylarthritis |
| D013166 | Spondylitis |
| D013122 | Spinal Diseases |
| D001847 | Bone Diseases |
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| baseline |
| Maximum difference in the ZTE signal value between healthy volunteers and patients with mechanical tendinopathy | baseline |
| D009140 |
| Musculoskeletal Diseases |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009135 | Muscular Diseases |
| D013708 | Tendon Injuries |
| D014947 | Wounds and Injuries |