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The main aim of the present study is to examine eye-tracking based markers for social processing deficits in children with autism spectrum disorder (ASD). To this end a battery of five eye-tracking paradigms will be administered to young children with ASD and typically developing children. To additionally evaluate the specificity of the eye-tracking markers a group of children with disorders of delayed development other than ASD will be included.
During an initial screening session all participants will undergo the Autism Diagnostic Observation Schedule (ADOS). ASD-related symptomatology and levels of impairments will be further characterized using the Social Responsibilities Scale 2 (SRS 2), Caregiver Strain Questionnaire (CSQ), Aberrant Behavior Checklist (ABC), Social Communication Questionnaire (SCQ), and Repetitive Behaviour Scale Revised (RBS-R).
Subsequently all participants will be administered the following eye-tracking paradigms: (1) dynamic social and non-social visual preference paradigm during which dynamic geometric images (DGI) and dynamic social images (DSI) will be presented, (2) non-biological versus biological motion paradigm, (3) social attention and sharing of enjoyment paradigm, (4) preference for real versus schematic emotional face stimuli paradigm during which photographs of human faces and emoticons will be presented, (5) shared social attention and gaze direction paradigm.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with Autism Spectrum Disorder | Children with an Autism Spectrum Disorder according to DSM-5 criteria |
| |
| Typically Developing Children | Typically developing children |
| |
| Children with Delayed Development Disorders | Children with Delayed Developmental Disorders other than ASD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Administration of five eye-tracking paradigms | Other | All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Global eye-gaze characteristics | Global eye-gaze patterns between the three groups will be compared to determine ASD specific alterations | Single assessment, total duration 20 minutes |
| Feature-specific eye-gaze characteristics | Localized feature-specific eye-gaze patterns will be compared between the three groups to determine ASD specific alterations | Single assessment, total duration 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Global eye-gaze characteristics and associations with symptom severity | Associations between global eye-gaze characteristics and severity of ASD symptoms | Single assessment, total duration 20 minutes |
| Feature-specific eye-gaze characteristics and associations with symptom severity |
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Exclusion criteria for all participants:
Inclusion criteria for all participants:
Additional inclusion criterion for the ASD group:
- diagnosis of Autism Spectrum Disorder according to DSM-5
Additional inclusion criteria for typically developing children in the control group:
Additional inclusion criterion for the unspecific disorder of delayed development children in the additional control group:
- disorder of delayed development other than ASD
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Children with ASD according to DSM-5 criteria will be compared with typically developing children and a group of children with unspecific delayed development disorders.
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| Name | Affiliation | Role |
|---|---|---|
| Juan Kou, MSc | University of Electronic Science and Technology of China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Life Science and Technology, University of Electronic Science and Technology of China | Chengdu | Sichuan | 610054 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31369217 | Derived | Kou J, Le J, Fu M, Lan C, Chen Z, Li Q, Zhao W, Xu L, Becker B, Kendrick KM. Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity. Autism Res. 2019 Oct;12(10):1529-1540. doi: 10.1002/aur.2174. Epub 2019 Aug 1. |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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Associations between localized feature-specific eye-gaze patterns and severity of ASD symptoms |
| Single assessment, total duration 20 minutes |