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The current study adresses the effect of two different computer-based cognitive trianing programmes on attention and executive functions in patients with Parkinson's disease.
The current study adresses the effect of two different computer-based cognitive training programmes (Brain+ Evolution and Scientific Brain Training PRO) on attention and executive functions in patients with Parkinson's disease. The patients are assigned to one of three groups. Two training groups with each their programme, and a control Group. The training groups will train at home for 8 weeks with follow-ups every second week. The control group will not train at home, but will also receive a follow-up with computer-based stimuli (computerized Card game) every second week, to minimize the possibility that a possible effect is due to the follow-up's with a professional, and not due to the computer training at home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Brain+ Evolution | Experimental | Intervention: Training with computer-based programme Brain+ Evolution for 8 weeks, receiving follow-ups every second week. Computer-based cognitive training. |
|
| Scientific Brain Training PRO | Experimental | Intervention: Training with computer-based programme Scientific Brain Training PRO for 8 weeks, receiving follow-ups every second week. Computer-based cognitive training. |
|
| Control group | No Intervention | This Group receives no intervention except for the same amount of follow-ups as the two training Groups. This is done to ensure that an effect of training is not aqtually due to the follow-up's with a professional. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computer-based cognitive training | Device | Computer-based cognitive programmes are computer programmes designed as games with the aim of training patients in certain cognitive domains. |
| Measure | Description | Time Frame |
|---|---|---|
| SDMT | Symbol digit modalities test, neuropsychological test of processing speed | 2 minutes |
| PDQ-39 | Parkinson's disease questionnaire; daily functioning and well-being in Parkinson's disease | 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| HADS | Hospital anxiety and depression screening | 10 minutes |
| Digit span | Digit span Wais-IV; Working memory | 10 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Annemette Løkkegaard, Ph.d. | Doctor | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bispebjerg Hospital | Copenhagen | Capital Region | 2400 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34986487 | Derived | Svaerke K, Faerk AK, Riis A, Stiegnitz von Ehrenfels SEM, Mogensen J, Lokkegaard A. Effects of Computer-Based Cognitive Rehabilitation on Attention, Executive Functions, and Quality of Life in Patients with Parkinson's Disease: A Randomized, Controlled, Single-Blinded Pilot Study. Dement Geriatr Cogn Disord. 2021;50(6):519-528. doi: 10.1159/000520591. Epub 2022 Jan 5. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Two intervention Groups training with each their computer-based cognitive programme, one control Group receiving no intervention except for the same amount of follow-ups as the two intervention Groups.
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Before and after the intervention period, the patients are tested in a neuropsychological battery to asses their executive functioning. The tester is blinded to the Group allocation of the patients.
| Verbal fluency | S-Words, animal-names and A/F-words | 3 minutes |
| Stroop colour/word test | Stroop colour/Word test, respone inhibition | 3 minutes |
| Trail Making A and B | Trail Making A and B, cognitive flexibility | 5 minutes |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |