Kinetics of Perioperative Circulating DNA in Cancer Surgery

Kinetics of Perioperative Circulating DNA in Cancer Surgery

The aim of this study was to determine the kinetics of perioperative circulating DNA in three types of cancer. This first step will enable further studies comparing the potential impact of certain techniques or anesthetic products on cancer surgery.

Inclusion Criteria:

• The patient must have given their free and informed consent and signed the consent form
• The patient must be a member or beneficiary of a health insurance plan
• The patient is aged between 18-75
• Patient must weigh >40kg
• The patient will receive adjusted carcinological surgery
• Indication of curative surgery
• The patient has already undergone tumoral biopsy prior to surgery
• The patient has stage M0 cancer of either colon (right or left colonic adenocarcinoma), prostate (adenocarcinoma) or breast (infiltrating carcinoma)

Exclusion Criteria:

• The subject is in a period of exclusion determined by a previous study
• The patient is under safeguard of justice
• The subject refuses to sign the consent
• It is impossible to give the subject informed information
• The patient is pregnant, parturient or breast feeding
• Chronic alcoholism
• The patient has received radiotherapy or chemotherapy periopratively
• Cancer other than colon, breast or prostate
• The patient has currently or in the past, had a cancerous lesion
• Neo-adjuvant therapy (immunotherapy, radiotherapy, chemotherapy)
• Emergency cancer surgery