Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Adaptative clinical trial (Dixon's Up and Down) for determination of ED95% of propofol concentration for hypnosis under general anesthesia for young and elderly adults.

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Method: adaptative clinical trial (Dixon's Up and Down method) for determination of ED95% of propofol concentration (plasmatic, Marsh model) for hypnosis (BIS ranging from 40 to 60) under general anesthesia for young and elderly adults.

Inclusion Criteria:

• Both sex
• Between 18-28 or 65-75 years old
• ASA physical status I or II
• no pre-anesthetic medications prescribed
• scheduled for surgery under general anesthesia
• willing to participate and sign informed consent.

Exclusion Criteria:

• Contraindications for propofol usage
• history of neurologic or psychiatric diseases
• drug abusers
• users of drugs that alter central nervous system
• pregnancy
• emergency surgeries
• rapid sequence intubation.