Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Research Foundation of Korea | OTHER |
| Seoul National University Bundang Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
Contrast-enhanced ultrasound(CEUS) of carotid artery plaque is a novel method that enabled direct visualization of neovessels in the vulnerable plaque. Plaque enhancement with CEUS showed correlation with the histologic density of neovessels within the carotid plaque and the previous cardiovascular events. Vulnerable plaques with a high risk of thromboembolic complications and rapid progression is associated with acute ischemic stroke. The prognostic value of vulnerable carotid artery plaque depicted with CEUS has not been fully investigated. The purpose of this study is to define prognostic value of plaque enhancement on carotid CEUS in acute stroke patients. Research question is; in acute ischemic stroke patients with ipsilateral carotid plaque as probable etiology of stroke, is the presence of carotid plaque enhancement on CEUS independent predictor of future stroke.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Composite of recurrent stroke, vascular death and myocardial infarction | (1) recurrent stroke: newly appeared DWI positive lesion on brain MRI with corresponding neurologic symptom (2) vascular death: sudden death, death due to stroke, myocardial infarction, heart failure, arrhythmia, pulmonary embolism, systemic bleeding, or ischemia of organ. (3) myocardial infarction: at least two of the followings: â‘ a history of typical angina pain. â‘¡ Elevation of Troponin, â‘¢ Newly developed ST change or Q waves or LBBB on ECG (outcomes will be measured by chart review or physician diagnosis or telephone interview) | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Ipsilateral stroke | Recurrent stroke of ipsilateral side (recurrent stroke at same side of previous infarction) | 12 months |
| All-cause mortality | All of the deaths, regardless of the cause |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Hospitalized acute ischemic stroke patients with ipsilateral carotid artery stenosis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yeo Koon Kim, MD | Contact | 82-10-3460-0660 | yeokoon@snubh.org | |
| Eun Jung Kim | Contact | 82-10-2450-3988 | jfhg92@naver.com |
| Name | Affiliation | Role |
|---|---|---|
| Yeo Koon Kim, MD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 13620 | South Korea |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| 12 months |
| Carotid intervention | Ipsilateral carotid endarterectomy or carotid artery stent insertion which was not planned when discharge. | 12 months |
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020521 | Stroke |