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This study evaluates the association between near infrared spectroscopy (NIRS) and indexed oxygen delivery (DO2i) and their possible correlation with postoperative organ failure.
Literature evidences show that levels of DO2i under 262-272 mL/min/m2 during cardiopulmonary by-pass (CPB) are associated with an increased incidence of acute kidney injury (AKI).
Furthermore, it has been demonstrated that keeping a NIRS of 75-80% compared to the basal value reduces the risk of perioperative morbidity. On the other hand, a NIRS < 50% of basal value seems to be predictive of an increase in morbidity.
All of those studies had been performed during CPB and knowledge lacks in management of DO2i and NIRS before and after CPB.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NIRS | Procedure | NIRS devices patch will be applied on patients' head in order to measure the cerebral saturation of each cerebral emisphere | ||
| DO2i | Other | Oxygen delivery standardized to the body surface area will be calculate in order to optimize tissue perfusion |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the correlation between NIRS and DO2i during cardiac surgery | Intraoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the correlation between NIRS, DO2i and SOFA score | 7 days postoperative |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing cardiac surgery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luca Salvi, MD | Contact | +390258002541 | luca.salvi@ccfm.it | |
| Matteo Nafi, MD | Contact | +390258002879 | matteo.nafi@ccfm.it |
| Name | Affiliation | Role |
|---|---|---|
| Luca Salvi, MD | Centro Cardiologico Monzino | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16305874 | Result | Ranucci M, Romitti F, Isgro G, Cotza M, Brozzi S, Boncilli A, Ditta A. Oxygen delivery during cardiopulmonary bypass and acute renal failure after coronary operations. Ann Thorac Surg. 2005 Dec;80(6):2213-20. doi: 10.1016/j.athoracsur.2005.05.069. | |
| 21831302 | Result | de Somer F, Mulholland JW, Bryan MR, Aloisio T, Van Nooten GJ, Ranucci M. O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: time for a goal-directed perfusion management? Crit Care. 2011 Aug 10;15(4):R192. doi: 10.1186/cc10349. |
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| ID | Term |
|---|---|
| D009102 | Multiple Organ Failure |
| ID | Term |
|---|---|
| D012769 | Shock |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 17646526 | Result | Nielsen HB, Borglum J. Cerebral oxygenation in heart surgery. Anesth Analg. 2007 Aug;105(2):537; author reply 538-9. doi: 10.1213/01.ane.0000265698.02800.d4. No abstract available. |
| 8844239 | Result | Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996 Jul;22(7):707-10. doi: 10.1007/BF01709751. No abstract available. |