Due to the difficulties of inclusion, it was decided not to extend this period

Metals and oxydes are found in welding fumes and are thought to participate in increasing cardiovascular risk in exposed workers. Investigators aimed to evaluate the impact of this occupational exposure on cardiovascular system in a highly exposed population, ship repairing welders and to compare this population to paired controls.

In an exposed-non-exposed study, investigators will include 30 welders and 30 airport runway agents for control. As part of cardiovascular independent risk factors, microvascular endothelial function will be evaluated directly by laser Doppler flowmetry. Blood samples will be also collected and circulating markers of endothelial function (VW factor, E-selectin, VCAM, ICAM, circulating DNA), inflammation (CRP, IL-1β, IL-8, TNFα, IL-10), platelet activation (procoagulant microparticles, thrombin generation, fibin monomer) will be measured. A complete clinical and functional cardiovascular status will be documented in every participant.

Inclusion Criteria:

• Male or Female ≥ 18 years
• Employee performing welding or airport operations
• free, informed and written consent
• Being affiliated to a social security system

Exclusion Criteria:

• Taking cardiovascular medications which modify endothelial function and / or coagulation (antiplatelet, antihypertensive, cardiotropic).
• People with a history of ischemic cardiovascular disease, thrombotic disease, chronic inflammatory disease
• Pregnant women
• People with health status would be likely, in the baseline state, to have parameters studied in the study disrupted.