Omega 3 Fatty Acids in Patients With Chronic Renal Disease

Effects of the Supplementation With Omega 3 Fatty Acids in Patients With Chronic Renal Disease

To study the tolerance and efficacy of an omega 3 fatty acids supplement on renal and vascular function and inflammatory parameters in patients with chronic renal disease

In a double blind trial in patients with chronic renal disease, the effects of a 3.7 g supplement of docosahexanoic and eicosapentanoic acids or a supplement of a similar dose of corn oil during 12 weeks, will be assessed on the following parameters:

1. Urine albumin excretion
2. Renal function measured with serum creatinine, cystatin C and beta-2 microglobulin
3. Carotid intima media thickness and pulse wave velocity
4. Inflammation status assessed measuring serum levels of C reactive protein and interleukin 6
5. Metabolic control of diabetes
6. Serum lipid levels

Inclusion Criteria:

• Urinary albumin excretion over 30 mg/g creatinin
• Chronic renal failure stage 2 to 4
• Absence of serious conditions such as cáncer, decompensated heart failure, chronic infections and severe arterial lesions

Exclusion Criteria:

• Blood glucose levels over 180 mg/dl or glycosilated hemoglobin over 8%
• Presence of cognitive impairment that does not allow to sigin a written informed consent
• Alcohol or illicit drug abuse