Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| City of Munich | OTHER_GOV |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.
Single nucleotide polymorphisms with known effects on Progranulin plasma concentrations will be assessed in a separate analysis. Expression levels of microRNAs isolated from plasma, circulating exosomes and blood cells will be determined by next-generation sequencing to characterize epigenetic influences on progranulin plasma levels.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sepsis | Patients with sepsis | ||
| Cardiac Surgery | Patients undergoing cardiac surgery | ||
| Healthy controls | Normal individuals |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Change in progranulin plasma concentrations during ICU - therapy | Blood samples will be taken at the abovementioned time points | ICU admission, day 1, day 4 of ICU therapy |
| Measure | Description | Time Frame |
|---|---|---|
| Change in miRNA expression levels in exosomes, serum and blood cells during ICU - therapy | Blood samples will be taken at the abovementioned time points | ICU admission, day 1, day 4 of ICU therapy |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients with Sepsis, Patients undergoing cardiac surgery, Healthy volunteers
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Gustav Schelling, M.D. | Department of Anaesthesiology LMU | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, LMU Munich | Munich | Bavaria | 81377 | Germany | ||
| Department of Anesthesiology, Klinikum Neuperlach |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34476621 | Derived | Brandes F, Borrmann M, Buschmann D, Meidert AS, Reithmair M, Langkamp M, Pridzun L, Kirchner B, Billaud JN, Amin NM, Pearson JC, Klein M, Hauer D, Gevargez Zoubalan C, Lindemann A, Chouker A, Felbinger TW, Steinlein OK, Pfaffl MW, Kaufmann I, Schelling G. Progranulin signaling in sepsis, community-acquired bacterial pneumonia and COVID-19: a comparative, observational study. Intensive Care Med Exp. 2021 Sep 3;9(1):43. doi: 10.1186/s40635-021-00406-7. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
Not provided
Not provided
Not provided
Not provided
Not provided
Serum, EDTA blood, blood cells (PAXGENE)
| Munich |
| Bavaria |
| 81737 |
| Germany |
| D013568 |
| Pathological Conditions, Signs and Symptoms |