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The investigators' goal is to compare the efficacy of three different management strategies (sacral neuromodulation, botulinum toxin, M receptor antagonist) in treating consistent OAB in patients with SVMs after surgery.
Spinal Vascular malformations (SVMs) are complex neurosurgical lesions and account for 3%-4% of all intradural spinal cord mass lesions, which can influence the function of bladder. The investigators' goal is to compare the efficacy of three different management strategies (sacral neuromodulation, botulinum toxin, M receptor antagonist) in treating consistent OAB (Overactive Bladder) in patients with SVMs after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with SVMs undergoing SNM | Experimental | patients with SVMs are of consistent OAB (Overactive Bladder) after surgery and undergo sacral neuromodulation (SNM) |
|
| patients with SVMs receiving BTXA | Experimental | patients with SVMs are of consistent OAB after surgery and accept botulinum toxin A (BTXA) injection |
|
| patients with SVMs receiving drug | Experimental | patients with SVMs are of consistent OAB (Overactive Bladder) after surgery and accept M receptor antagonist |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| surgery | Procedure | patients with SVMs receive surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| bladder function | bladder function change in urodynamics | 3 months and 12 months |
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Inclusion Criteria:
•Patient diagnosed with spinal vascular diseases including Intradural arteriovenous malformation,Intradural arteriovenous fistula,Dural arteriovenous fistula,Extradural arteriovenous malformation,Paravertebral arteriovenous malformation,Paravertebral arteriovenous fistula,cobbs' syndrome,and other spinal arteriovenous metameric syndromes involve the spinal cord.
Exclusion Criteria:
•patient received surgical treatment or interventional treatment before
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| zhenhua shang, M.D | Contact | 17801117318 | shangzhenhua16@126.com |
| Name | Affiliation | Role |
|---|---|---|
| tongwen ou, M.D | Xuanwu Hospital, Beijing | Study Director |
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| sacral neuromodulation | Procedure | sacral neuromodulation (SNM) with InterStimTM |
|
| botulinum toxin A injection | Procedure | BOTOX |
|
| M receptor antagonist | Drug | Tolterodine |
|
|
| ID | Term |
|---|---|
| D053201 | Urinary Bladder, Overactive |
| ID | Term |
|---|---|
| D001745 | Urinary Bladder Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D059411 | Lower Urinary Tract Symptoms |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D019274 | Botulinum Toxins, Type A |
| D000068737 | Tolterodine Tartrate |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |
| D010665 | Phenylpropanolamine |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D001559 | Benzhydryl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D003408 | Cresols |
| D010636 | Phenols |
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