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| Name | Class |
|---|---|
| Landstinget i Värmland | OTHER |
| Dalarna County Council, Sweden | OTHER |
| Uppsala University Hospital | OTHER |
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The overall rationale is to reduce the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy (HCM). The novel approach of this study is to correlate Positron Emission Tomography (PET) findings to ventricular arrhythmias detected by the implantable cardioverter defibrillator (ICD). This could potentially lead to an improved risk stratification of HCM patients.
Positron Emission Tomography (PET) is a functional imaging technique that utilizes radioactive tracers to gain information on physiological or pathophysiological processes in vivo. Different tracers can provide information on different processes of interest. In cardiology, metabolic processes consuming oxygen (aerobic) can be studied with 11-Carbon-Acetate, sympathetic innervation can be studied with 11-Carbon-hydroxyephedrine and using 15-Oxygen-water the myocardial blood flow. Structural information of the heart such as left ventricular mass, left ventricular volumes and wall thickness can also be calculated with PET.
The aim is to correlate PET parameters and burden of ventricular arrhythmias in order to improve risk stratification in HCM.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Positron Emission Tomography | Diagnostic Test | Positron Emission Tomography |
| Measure | Description | Time Frame |
|---|---|---|
| Ventricular tachycardia (VT) vs myocardial blood flow | Ventricular tachycardia vs positron emissions tomography parameter Myocardial blood flow (MBF) | History of VT since receiving an implantable defibrillator within last 15 years |
| Ventricular tachycardia (VT) vs ejection fraction | Ventricular tachycardia vs positron emissions tomography parameter ejection fraction (EF) | History of VT since receiving an implantable defibrillator within last 15 years |
| Ventricular tachycardia (VT) vs mass | Ventricular tachycardia vs positron emissions tomography parameter mass | History of VT since receiving an implantable defibrillator within last 15 years |
| Ventricular tachycardia (VT) vs wall thickness | Ventricular tachycardia vs positron emissions tomography parameter wall thickness | History of VT since receiving an implantable defibrillator within last 15 years |
| Ventricular tachycardia (VT) vs oxygen consumption | Ventricular tachycardia vs positron emissions tomography parameter oxygen consumption (MVO2) | History of VT since receiving an implantable defibrillator within last 15 years |
| Ventricular tachycardia (VT) vs sympathetic innervation | Ventricular tachycardia vs positron emissions tomography parameter sympathetic innervation (retention index) | History of VT since receiving an implantable defibrillator within last 15 years |
| Measure | Description | Time Frame |
|---|---|---|
| Atrial fibrillation (AF) vs myocardial blood flow | Atrial fibrillation vs positron emissions tomography parameter myocardial blood flow | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs ejection fraction |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with hypertrophic cardiomyopathy (HCM) and an implantable defibrillator (ICD)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Peter Magnusson, MD | Contact | +46705089407 | peter.magnusson@regiongavleborg.se | |
| Jonny Nordström, MSc | Contact | +46725727670 | jonny.nordstrom@regiongavleborg.se |
| Name | Affiliation | Role |
|---|---|---|
| Jens Sörensen, MD PhD | Region Gävleborg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Region Gavleborg | Recruiting | Gävle | 80324 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25173338 | Background | Authors/Task Force members; Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G, Mahrholdt H, McKenna WJ, Mogensen J, Nihoyannopoulos P, Nistri S, Pieper PG, Pieske B, Rapezzi C, Rutten FH, Tillmanns C, Watkins H. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014 Oct 14;35(39):2733-79. doi: 10.1093/eurheartj/ehu284. Epub 2014 Aug 29. No abstract available. | |
| 10952953 |
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| ID | Term |
|---|---|
| D002312 | Cardiomyopathy, Hypertrophic |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001020 | Aortic Stenosis, Subvalvular |
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| ID | Term |
|---|---|
| D049268 | Positron-Emission Tomography |
| ID | Term |
|---|---|
| D014055 | Tomography, Emission-Computed |
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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| Ventricular tachycardia (VT) vs myocardial external efficiency |
Ventricular tachycardia vs positron emissions tomography parameter myocardial external efficiency (MEE) |
| History of VT since receiving an implantable defibrillator within last 15 years |
| Ventricular tachycardia (VT) vs stroke work | Ventricular tachycardia vs positron emissions tomography parameter stroke work (SW) | History of VT since receiving an implantable defibrillator within last 15 years |
Atrial fibrillation vs positron emissions tomography parameter ejection fraction (EF) |
| History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs mass | Atrial fibrillation vs positron emissions tomography parameter mass | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs wall thickness | Atrial fibrillation vs positron emissions tomography parameter wall thickness | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs oxygen consumption | Atrial fibrillation vs positron emissions tomography parameter oxygen consumption (MVO2) | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs sympathetic innervation | Atrial fibrillation vs positron emissions tomography parameter sympathetic innervation (retention index) | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs myocardial external efficiency | Atrial fibrillation vs positron emissions tomography parameter myocardial external efficiency (MEE) | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial fibrillation (AF) vs stroke work | Atrial fibrillation vs positron emissions tomography parameter stroke work (SW) | History of VT since receiving an implantable defibrillator within last 15 years |
| Atrial size vs ventricular tachycardia | atrial diameter, volume vs ventricular tachycardia | History of VT since receiving an implantable defibrillator within last 15 years |
| Background |
| Maron BJ, Olivotto I, Spirito P, Casey SA, Bellone P, Gohman TE, Graham KJ, Burton DA, Cecchi F. Epidemiology of hypertrophic cardiomyopathy-related death: revisited in a large non-referral-based patient population. Circulation. 2000 Aug 22;102(8):858-64. doi: 10.1161/01.cir.102.8.858. |
| 20069294 | Background | Timmer SA, Germans T, Gotte MJ, Russel IK, Dijkmans PA, Lubberink M, ten Berg JM, ten Cate FJ, Lammertsma AA, Knaapen P, van Rossum AC. Determinants of myocardial energetics and efficiency in symptomatic hypertrophic cardiomyopathy. Eur J Nucl Med Mol Imaging. 2010 Apr;37(4):779-88. doi: 10.1007/s00259-009-1350-3. Epub 2010 Jan 13. |
| 12651046 | Background | Kofflard MJ, Ten Cate FJ, van der Lee C, van Domburg RT. Hypertrophic cardiomyopathy in a large community-based population: clinical outcome and identification of risk factors for sudden cardiac death and clinical deterioration. J Am Coll Cardiol. 2003 Mar 19;41(6):987-93. doi: 10.1016/s0735-1097(02)03004-8. |
| 21377644 | Background | Timmer SA, Germans T, Gotte MJ, Russel IK, Lubberink M, Ten Berg JM, Ten Cate FJ, Lammertsma AA, Knaapen P, van Rossum AC. Relation of coronary microvascular dysfunction in hypertrophic cardiomyopathy to contractile dysfunction independent from myocardial injury. Am J Cardiol. 2011 May 15;107(10):1522-8. doi: 10.1016/j.amjcard.2011.01.029. Epub 2011 Mar 4. |
| D001024 |
| Aortic Valve Stenosis |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D003933 | Diagnosis |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011877 | Radionuclide Imaging |
| D014054 | Tomography |
| D003947 | Diagnostic Techniques, Radioisotope |