Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The experience of pain derives from changes in brain excitability. Therefore, modulating the excitability of cortical areas involved in pain processing may become an attractive option in the context of multimodal analgesia during the postoperative period.
The combination of analgesic drugs acting on different mechanisms can potentiate the effects of analgesia. Moreover, the understanding of pain physiology at the molecular level supports the development of new specific drugs. Indeed, new neurophysiological models of pain processing by the brain are becoming exquisitely refined and are supported by electrophysiological and functional brain imaging studies. One of the interesting concepts that stemmed from these studies is the evidence that the experience of pain is reflected in the central nervous system by widespread activations and excitability changes within a network of interconnected cortical areas and subcortical structures. The network processing of noxious information and their limbic and emotional consequences has been termed the "pain matrix." The continuous observation of the activity and excitability changes that parallel the pain experience led to the development of a new therapeutic approach: the use of central nervous system stimulation techniques.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS sham motor cortex | Sham Comparator | 25 participants will have sham stimulation for 20 minutes using transcranial direct current stimulation device. |
|
| Active motor cortex stimulation | Active Comparator | 25 participants will have active stimulation targeting the left motor cortex for 20 minutes using transcranial direct current stimulation device. |
|
| active prefrontal cortex stimulation | Active Comparator | 25 participants will have active stimulation targeting the left dorsolateral prefrontal cortex for 20 minutes using transcranial direct current stimulation device. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS sham motor cortex | Device | the intervention 25 participants will be subjected to spine surgery then participants will be subjected to sham stimulation targeting left motor cortex area using the transcranial direct current stimulation device for 30 seconds then stop for 20 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| the total consumption of morphine administered by patients during the first two days postoperative | the investigator will calculate the amount of morphine used during the first two days postoperative. | 48 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Pain severity assessment using visual analogue scale (VAS score from 0-10) | the investigator will assess the pain at base line and at the end of sessions | 30 minutes after every sessions and at the third day |
| HADS score |
Not provided
Inclusion Criteria:
Exclusion Criteria: the participant who has any history of:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Saeid M Elsawy, MBBch | Assiut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saeid Metwaly Elsawy | Asyut | 71111 | Egypt | |||
| Saeid Elsawy |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| active prefrontal cortex stimulation | Device | the intervention 25 participants will be subjected to spine surgery then participants will be subjected to an active stimulation targeting left dorsolateral prefrontal cortex area using the transcranial direct current stimulation device with a current intensity of 2 mA for 20 min |
|
| active motor cortex stimulation | Device | the intervention 25 participants will be subjected to spine surgery then participants will be subjected to an active stimulation targeting left motor cortex area using the transcranial direct current stimulation device with a current intensity of 2 mA for 20 min |
|
hospital anexiety and depression score
| before surgery and at the third day |
| London |
| N15 4DW |
| United Kingdom |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
Not provided
Not provided