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Anorexia Nervosa (AN) is a serious and often chronical eating disorder characterized by an extreme effort for weight loss and intense fear of becoming fat despite the obvious thinness. The treatment is very difficult and not always effective. That´s the reason why we are looking for new ways of the therapeutic approach.
Transcranial direct current stimulation (tDCS) is a neuromodulation technique, which modulates the neuronal excitability. According to previous research it has a potential to help people with Anorexia Nervosa.
The device for the tDCS has two electrodes, an anode (the excitatory one) and a cathode (the inhibitory one). We put them on the skull into the different positions, in dependence on the fact, if we want to excite or on to inhibit the parts of the brain under the electrodes.
There are several hypothesis how could the tDCS help in patients with AN. One of them speaks about the hyperactivity of the right hemisphere in Anorexia Nervosa. Therefore could the anodal (excitatory) tDCS over the left hemisphere and the cathodal (inhibitory one) help in resetting the inter-hemispheric balance.
Stimulation of 2 milliampere is applied for 30 minutes in every real session. Together there are 10 sessions, the application is every workday within 2 weeks.
All measurements and questionnaires are made 4 times:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tDCS | Experimental | The first group of patients has the real stimulation and the electrodes are placed in this position: Anode: Left DLPFC [F3) Cathode: Right Supraorbital (FP2)](streamdown:incomplete-link) |
|
| Sham tDCS | Sham Comparator | The second group has the sham stimulation, but the electrodes are placed in the same position as in the first group: Anode: Left DLPFC [F3) Cathode: Right Supraorbital (FP2)](streamdown:incomplete-link) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Anodal tDCS | Device | This group gets a real stimulation |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the Eating Disorders Examination Questionnaire (EDEq) score | Comparison of the total scores and subscores of the Eating Disorders Examination Questionnaire (EDEq) | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change of the Zung Self-Rating Depression Scale | Comparison of the total scores of the Zung Self-Rating Depression Scale | 8 weeks |
| Change of the pain threshold | Measurement of the pain threshold with the TSA II Neuro Sensory Analyzer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hana Papezova, Prof.,M.D.,CSc. | Department of Psychiatry, Charles University in Prague and General University Hospital in Prague | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry, Charles University in Prague and General University Hospital in Prague | Prague | 121 08 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34690831 | Derived | Baumann S, Mares T, Albrecht J, Anders M, Vochoskova K, Hill M, Bulant J, Yamamotova A, Stastny O, Novak T, Holanova P, Lambertova A, Papezova H. Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa. Front Psychiatry. 2021 Oct 6;12:717255. doi: 10.3389/fpsyt.2021.717255. eCollection 2021. |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Sham tDCS |
| Device |
This group gets a sham stimulation |
|
| 8 weeks |
| Change of the weight in kilograms | Regularly weighting on the scale | 8 weeks |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |