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Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's disease was performed. Genome-wide DNA methylation was determined using the Illumina HumanMethylation 850k BeadChip.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inflamed CD group | Inflamed ileal mucosa was obtained from inflammed lesions of active CD patients |
| |
| Non-inflamed CD group | Non-inflamed ileal mucosa was obtained from normal sites of active CD patients |
| |
| Control group | Control ileal mucosa was obtained from healthy patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Genome-wide DNA methylation | Genetic | Genome-wide DNA methylation was determined using the Infinium Human Methylation 850K BeadChip. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intestinal inflammation under colonoscopy | Intestinal ulcer or enteritisis observed under colonoscopy | Jan 2017 to Sep 2017 |
| Measure | Description | Time Frame |
|---|---|---|
| CDAI | Crohns Disease Activity Index is measured. | Jan 2017 to Sep 2017 |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with active Crohn's disease who underwent colonoscopy at Jinling Hospital
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jinling Hospital | Recruiting | Nanjing | Jiangsu | 210002 | China |
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| ID | Term |
|---|---|
| D003424 | Crohn Disease |
| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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inflamed and non-inflamed ileal mucosa of patients with Crohn's disease and normal ileal mucosa of healthy controls
| D007410 | Intestinal Diseases |