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Thyroid gland surgery is one of the most commonly performed operations for either benign or malignant pathologies Pain related to thyroid surgery is of moderate intensity .which may be treated with NSAIDs or opioids. However, Opioids have many well-known undesirable effects, including postoperative nausea and vomiting, which are frequent after this type of procedure.
Regional techniques of anesthesia may help to decrease post-operative pain and reduce systemic analgesic requirement. Classically, the cervical plexus is considered to have two distributions, the superficial cutaneous and the deep motor nerves.
Anatomically, the thyroid gland has an inner true capsule which is thin and adheres closely to the thyroidal tissue [Fancy et al., 2010]. External to this is a false capsule formed by the middle layer of the deep cervical fascia, which splits anterolaterally to ensheathe the thyroid gland, thus forming the thyroid sheath [Bliss et al., 2000]. In this fashion, the potential space called the capsule-sheath space is formed. It contains also loose connective tissue, blood vessels, nerves and parathyroid gland. Anesthetic deposited in this space would block the surface of thyroid gland and permeate directly into the parenchyma producing effective local anesthesia for thyroid surgical procedures. It is supposed also to involve autonomic nerve block of the thyroid gland [Fliers et al., 2010]. Additionally, a subcutaneous injection along the sternocleidomastoid muscle (SCM) would also enhance effective local anesthesia for the initial skin incision and further contribute to a more ideal working environment for the surgeon. Therefore, anesthetic technique termed ultrasound-guided capsule-sheath space block (CSSB) combined with anterior cervical cutaneous nerves block (CCNB) for thyroidectomy is done [Wang et al., 2015] .
Our hypothesis is that a combination of simple dual techniques including superficial cutaneous block to provide sensory blockade, and surgeon mediated capsular block may afford autonomic thyroid blockade. In comparison, ultrasound guided intermediate cervical plexus block may provide these blocks but using a machine and deep penetration possibly involving unwanted blocks for phrenic and recurrent laryngeal nerves. So, if the simple safe technique can provide the same intra and postoperative anesthetic conditions it will be preferred.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Capsule and cutaneous blocks | Experimental | 7.5 mL of 0.5% bupivacaine + Epinephrine 5 ug/ ml for both blocks per side. once before surgery |
|
| US-intermediate cervical plexus block | Active Comparator | 15 mL of 0.5% isobaric bupivacaine + Epinephrine 5 microgram/ ml. per side. once before surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Capsule and cutaneous blocks | Procedure | 7.5 mL of 0.5% bupivacaine + Epinephrine 5 ug/ ml for both blocks once before surgery per side |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total dose of opioid analgesics used | The total dose of opioid analgesics required in the post-operative periods | For 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain | Postoperative visual analogue score (VAS) (0 no pain -10 worst imaginable pain), | For 24 hours after surgery |
| Time to first analgesic request | Time to first request for a rescue analgesic |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Moneir O El-Hefny, MD | Professor of Anesthesia and Surgical Intensive Care | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oncolgy Center, Mansoura University, | Al Mansurah | DK | 53316 | Egypt |
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| US-intermediate cervical plexus block | Procedure | 15 mL of 0.5% bupivacaine + Epinephrine 5 ug/ ml once before surgery per side. |
|
| For 24 hours after surgery |
| Fentanyl use | Intraoperative use of fentanyl | For 5 hours after start of anaesthesia |
| Rocuronium use | Intraoperative use of rocuronium | For 5 hours after start of anaesthesia |
| Sensory blockade | Assessment of sensory blockade | for 1 hour after surgery |
| Diaphragmatic dysfunction | Diaphragmatic dysfunction using ultrasound assessment and possible x ray | for 5 hours after performing blockade |
| Sedation score | Sedation score using Modified Ramsay scale | for 5 hours after performing blockade |
| Patient satisfaction | Patient satisfaction regards analgesia using a score of (0-10) with 10 represents the highest satisfaction | for 24 hrs after surgery |
| Postoperative nausea and vomiting | frequency | For 24 hours after surgery |
| Postoperative headache | frequency | For 24 hours after surgery |
| Hoarseness of voice | frequency | For 24 hours after surgery |
| Dysphagia | frequency | For 24 hours after surgery |
| Respiratory difficulty | Peripheral oxygen saturation less than 92% | For 24 hours after surgery |