Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia

Thrombotic Biomarkers to Predict Thrombosis in Heparin-induced Thrombocytopenia

Heparin induced thrombocytopenia (HIT) is a kind of catastrophic thrombotic complications after the application of heparin. If HIT without treatment, death rate is as high as 30% to 50%. Early diagnosis of HIT and prevention of thrombosis is very important.

This study is planned to assess the use of thrombotic biomarkers in patients with HIT, including thrombin-antithrombin complex, d-dimer, fibrin degradation products and Thrombelastograghy monitoring . These biomarkers are monitored in 5-14 days post-operation to assess the risk of thrombosis in HIT patients. All patients were followed up for 30 days, and clinical outcomes, including new thrombus and death, were recorded during follow-up.

Inclusion Criteria:

• Hospitalized patients undergoing cardiac surgery.
• Receiving unfractionated heparin anticoagulation.

Exclusion Criteria:

• history of heparin-induced thrombocytopenia
• pregnant woman