• Thrombus Composition in Cerebral Infarctions: Study of Its Association With Plasma Biomarkers, Treatment Efficacy, Etiology and Prognosis.

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ClinicalTrials.gov ID

NCT03268668

Lead Sponsor

Fondation Ophtalmologique Adolphe de RothschildNETWORK

Overall Status

Recruiting

Study Type

Observational

Enrollment

1,200Estimated

Last Update Posted

Jan 20, 2026Actual

Start Date

Jul 13, 2017Actual

Primary Completion Date

Jul 12, 2027Estimated

Completion Date

Jan 1, 2028Estimated

Official Title

Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis

Brief Summary

The recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes. This treatment option also opens up a new field of research, making possible the analysis of the clot responsible for intracranial occlusion. Indeed, in about 30% of the cases, the thrombectomy procedure makes it possible to retrieve either partially or completely the clot. Previous studies have analyzed the correlation between the composition of the thrombus and the etiology of stroke. Their discordant results do not yet make it possible to distinguish a particular profile of thrombus according to etiology. Other studies have shown a correlation between the proportion of red blood cells in a thrombus and the likelihood that it is visible in MRI or cerebral scanning. More recently, one study has demonstrated a correlation between the presence of lymphocytes in the thrombus and an atheromatous etiology.

The main limitations of these studies are the small number of patients included, the high variability of conservation protocols and the absence of plasma data, which does not allow for research on the correlation between clot composition and plasma biomarkers.

• Stroke, Acute
• Biological Specimen Banks
• Biomarkers
• Etiology
• Prognosis

• Collection of thrombus that is responsible for stroke and blood sample

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Patients aged 18 years and older
• Presenting with cerebral infarction following arterial occlusion
• Treated for mechanical thrombectomy (whether performed or not)
• Free, informed, and express consent of the patient or their relatives (emergency inclusion procedure)
• For retrospective patients: thrombus already collected (according to the center's usual practice or for another research project).

Exclusion Criteria:

• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman

Observational Model

Case-Only

Time Perspective

Cross-Sectional

Lead Sponsor

Fondation Ophtalmologique Adolphe de RothschildNETWORK

barbier-ch@chu-caen.fr02 31 06 46 91 ext. + 33