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| Name | Class |
|---|---|
| Ospedale San Raffaele | OTHER |
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This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.
The investigators will collect plasma and cardiac tissue specimens from consenting subjects. The investigators will evaluate the expression of mRNAs, miRNAs and lncRNAs in patients affected by both end-stage and not end-stage HF as well as in patients affected by aortic stenosis and undergoing valve replacement and requiring cardiac myectomy. The tissue dysregulated RNAs will be next measured in plasma samples in order to clarify their potential as biomarkers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non end-stage heart failure | Measurement of RNAs in non end-stage heart failure patients undergoing to left ventricle reconstruction |
| |
| End-stage heart failure | Measurement of RNAs in end-stage heart failure patients undergoing to left ventricular assisted device (LVAD) |
| |
| Aortic Stenosis | Measurement of RNAs in patients affected by cardiac hypertrophy leading to aortic stenosis and requiring cardiac myectomy |
| |
| Controls | Measurement of RNAs in individuals not affected by cardiovascular diseases |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| measurement of RNAs | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac tissutal mRNAs signatures | The mRNAs cardiac tissutal signatures of non- and end-stage heart failure patients and of aortic stenosis patients compared to controls | from Year 1 to Year 3 |
| Cardiac tissutal miRNAs signatures | The miRNAs cardiac tissutal signatures of non- and end-stage heart failure patients and of aortic stenosis patients compared to controls | from Year 1 to Year 3 |
| Cardiac tissutal lncRNAs signatures | The lncRNAs cardiac tissutal signatures of non- and end-stage heart failure patients and of aortic stenosis patients compared to controls | from Year 1 to Year 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Non end-stage, end-stage heart failure, aortic stenosis mRNAs signatures in plasmas | The mRNAs dysregulated in cardiac tissues will be measured in blood plasma samples of non- and end-stage heart failure patients and of aortic stenosis patients compared to controls | from Year 3 to Year 5 |
| Non end-stage, end-stage heart failure, aortic stenosis miRNAs signatures in plasmas |
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Inclusion Criteria:
Non end-stage heart failure
End-stage heart failure
Aortic Stenosis
Exclusion Criteria:
Non end-stage heart failure
End-stage heart failure
Aortic Stenosis
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Cardiac surgery patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fabio Martelli, Dr | Contact | +39 02 26437762 | fabio.martelli@grupposandonato.it |
| Name | Affiliation | Role |
|---|---|---|
| Fabio Martelli, Dr | IRCCS Policlinico S. Donato | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Irccs Policlinico San Donato | Recruiting | San Donato Milanese | Milan | 20097 | Italy |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
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cardiac tissue and blood samples
The miRNAs dysregulated in cardiac tissues will be measured in blood plasma samples of non- and end-stage heart failure patients and of aortic stenosis patients compared to controls |
| from Year 3 to Year 5 |
| Non end-stage, end-stage heart failure, aortic stenosis lncRNAs signatures in plasmas | The lncRNAs dysregulated in cardiac tissues will be measured in blood plasma samples of non- and end-stage heart failure patients and of aortic stenosis patients compared to controls | from Year 3 to Year 5 |
| Ospedale San Raffaele | Recruiting | Milan | 20132 | Italy |
|
| D014694 |
| Ventricular Outflow Obstruction |