Study of the Transcriptomic Alterations in Heart Failure and Aortic Stenosis
Study of the Transcriptomic Alterations in Heart Failure and Aortic Stenosis
This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.
The investigators will collect plasma and cardiac tissue specimens from consenting subjects. The investigators will evaluate the expression of mRNAs, miRNAs and lncRNAs in patients affected by both end-stage and not end-stage HF as well as in patients affected by aortic stenosis and undergoing valve replacement and requiring cardiac myectomy. The tissue dysregulated RNAs will be next measured in plasma samples in order to clarify their potential as biomarkers.
Inclusion Criteria:
Non end-stage heart failure
End-stage heart failure
Aortic Stenosis
Exclusion Criteria:
Non end-stage heart failure
End-stage heart failure
Aortic Stenosis
fabio.martelli@grupposandonato.it+39 02 26437762
San Donato Milanese, Milan 20097, Italy
fabio.martelli@grupposandonato.it0252774683
debonis.michele@hsr.it