COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old

COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old.

Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.

Inclusion Criteria:

• Personal or familial cognitive complaints
• Individual aged ≥ 65 years old and < 81 years old
• Instrumental activities of daily living (IADL) score between 3-4
• French speaking individual
• Informed consent signed For PLHIV
• HIV infection
• Undetectable HIV viral load ≥ 1 year
• Current cluster of differentiation (CD4) cell count > 100/mm3 For controls
• negative HIV serology ≤ 6 months

Exclusion Criteria:

• Opportunistic infection < 5 years
• Contraindications to MRI