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| Name | Class |
|---|---|
| Topcon Corporation | INDUSTRY |
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This is a study of the compliance of the lamina cribrosa with change in eye pressure.
Glaucoma patients and control subjects will have their internal eye structure (lamina cribrosa) imaged by optical coherence tomography (OCT) standard images at two different eye pressures. In some participants, the eye pressure will be changed by one of two interventions, wearing goggles or having laser suturelysis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| persons drinking water | Experimental | all persons in the study will have images of the eye at baseline eye pressure, then the intervention will be to drink 2 bottles of water to increase eye pressure or decrease eye pressure, then will have images taken a second time |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| wearing swimming goggles or having laser suturelysis | Other | Two images will be compared in each subject at two different eye pressures with the higher pressure having been produced by the interventions |
| Measure | Description | Time Frame |
|---|---|---|
| Change in anterior lamina cribrosa depth | OCT position of lamina measured at 2 eye pressures. Data will be calculated as change in parameters of interest per mm Hg change in eye pressure | Up to 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Harry A Quigley, MD | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University | Baltimore | Maryland | 21287 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39630437 | Derived | Czerpak CA, Kashaf MS, Zimmerman BK, Mirville R, Gasquet NC, Quigley HA, Nguyen TD. The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients. Transl Vis Sci Technol. 2024 Dec 2;13(12):7. doi: 10.1167/tvst.13.12.7. | |
| 38272391 | Derived | Czerpak CA, Quigley HA, Nguyen TD. Long-term Remodeling Response in the Lamina Cribrosa Years after Intraocular Pressure Lowering by Suturelysis after Trabeculectomy. Ophthalmol Glaucoma. 2024 May-Jun;7(3):298-307. doi: 10.1016/j.ogla.2024.01.003. Epub 2024 Jan 24. |
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deidentified information (imaging data) will be shared after initial publication
after initial publication, indefinitely
no restrictions
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| 37645852 | Derived | Hannay V, Czerpak CA, Quigley HA, Nguyen TD. A noninvasive clinical method to measure in vivo mechanical strains of the lamina cribrosa by optical coherence tomography. medRxiv [Preprint]. 2023 Aug 16:2023.08.14.23294082. doi: 10.1101/2023.08.14.23294082. |
| 35863747 | Derived | Czerpak CA, Kashaf MS, Zimmerman BK, Quigley HA, Nguyen TD. The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma. Ophthalmol Glaucoma. 2023 Jan-Feb;6(1):11-22. doi: 10.1016/j.ogla.2022.07.005. Epub 2022 Jul 19. |