Not provided
Not provided
Not provided
Not provided
Not provided
No patients
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of this study is to investigate quantitative improvement in excessive tearing after administration of Bupivacaine, a local anesthetic, into the affected eyelids.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.75% bupivacaine | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.75% bupivacaine | Drug | topical anesthetic |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Lacrimal Tear Lake at 6 months | Measurement of the height (in mm) of the tear film in the lower conjunctival cup de sac, obtained during slit lamp examination of the eye | measurements at baseline and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline Lid distraction at 6 months | distance (in mm) that the eyelids can be maximally pulled from the globe | measurements at baseline and 6 months |
| Change from baseline Lid snap back at 6 months |
Not provided
Inclusion Criteria:
Patients age 18 and above, patients with unilateral or bilateral excessive tearing.
Exclusion Criteria:
Pregnant females, vulnerable populations, patients with severe hepatic disease, or patients using monoamine oxidase inhibitors or tricyclic antidepressants, which are contraindicated with bupivacaine and norepinephrine combinations.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Albert Y Wu, MD PhD | Icahn School of Medicine at Mount Sinai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D001763 | Blepharoptosis |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D005141 | Eyelid Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Amount of time (in sec) it takes for the lids to return to their normal anatomical position after being pulled to their maximum excursion with fingers
| measurements at baseline and 6 months |
| D000588 |
| Amines |