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Despite PH adjustment of local anesthetic solution improves the quality of the block in all respects with special advantage of early onset of sensory and motor block, adequate level of analgesia, and prolongation of duration of block, the effect of warmed bupivacaine should have the same effect which have not been evaluated on supraclavicular plexus block for upper limb surgery.
The warmed bupivacaine used in supraclavicular plexus block may reduce sensory and motor block onset and prolong the duration of analgesia when compared to bupivacaine at operating room temperature.
The aim of this study is to compare the effect of warm bupivacaine 0.5% at 37◦C versus bupivacaine 0.5% at operating room temperature at 23◦C on ultrasound-guided supraclavicular plexus block characteristics as regard sensory block onset time, motor block onset time, duration of sensory and motor block , effective duration of analgesia, total analgesics requirement, complications and side effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Warm bupivacaine at (37°c) | Experimental | Warmed bupivacaine at body temperature will be administered |
|
| Bupivacaine at operating room temperature (23°c) | Active Comparator | Bupivacaine at temperature of 23°C will be administered |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Warm bupivacaine at (37°c) | Drug | Bupivacaine 0.5%, 30 mL, warmed to 37◦C for 20 minutes. The empty syringes and needles, in their packaging, will be held at the same temperature before initiating the block. |
| Measure | Description | Time Frame |
|---|---|---|
| Time to onset of sensory block | defined as the time interval between the end of local anesthetic injection and the loss of sensation to pinprick (sensory score = 1) | for 30 min following injection |
| Measure | Description | Time Frame |
|---|---|---|
| Time to onset of motor block | defined as time interval between the end of local anesthetic injection and (motor score = 1) in the distributions of all 4 peripheral nerves. | For 3 hours after the injection of local anesthetic |
| Heart rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed Y Makharita, MD | Professor of Anesthesia and Surgical Intensive Care | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University, Faculty of Medicine | Al Mansurah | DK | 050 | Egypt |
do not mind sharing raw data but after its publication not before.
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Double-blind design
| Bupivacaine at operating room temperature (23°c) | Drug | Bupivacaine 0.5%, 30 ml held in crash shelf of the operating room temperature at 23◦C. The empty syringes and needles will be held in the same temperature before use. |
|
| For 3 hours after the injection of local anesthetic |
| Blood pressure | For 3 hours after the injection of local anesthetic |
| oxygen saturation in the peripheral blood | For 3 hours after the injection of local anesthetic |
| Duration of sensory block | defined as the interval between end of injection and complete end of sensory block (score=2) | For 24 hours after the injection of local anesthetic |
| Duration of motor block | defined as the interval between end of injection and complete recovery of normal motor function (score=0), respectively. | For 24 hours after the injection of local anesthetic |
| The severity of postoperative pain | will be measured and recorded by using a 100-cm visual analog scale (VAS) for pain, where 0 is equal to no pain and 100 indicates the worst possible pain. | For 24 hours after the injection of local anesthetic |
| Time for first analgesic request | Time to the first receiving of rescue analgesic from the time of blockade | For 24 hours after the injection of local anesthetic |
| Total analgesics received | Cumulative use of rescue analgesics after performing the blockade | for 24 hrs after the injection of local anesthetic |
| Satisfaction Score | Using score including 5-Excellent, 4-Very Good, 3-Good, 2-Fair, and 1-Poor | for 48 hrs after the injection of local anesthetic |