Prebiotics in Peritoneal Dialysis

Prebiotics in Peritoneal Dialysis

The Prebiotics in Peritoneal Dialysis trial is a non-randomized, open-label, crossover study of p-inulin for patients with end-stage renal disease treated with peritoneal dialysis.

Inclusion Criteria:

• Peritoneal dialysis therapy for end-stage renal disease
• ≥30 days since dialysis initiation
• Ability to provide informed consent

Exclusion Criteria:

• Use of pre- or pro-biotics during the past 2 months
• Consumption of pro-biotic yogurt during the past 2 weeks
• Use of antibiotics within the past 2 months
• Presence of chronic infection
• Chronic gastrointestinal condition other than constipation
• Cirrhosis or chronic active hepatitis
• Stomach/intestinal resection
• PD access problems
• Anticipated kidney transplant or transfer to another dialysis unit within 9 months
• Expected survival < 9 months
• Pregnancy, anticipated pregnancy, or breastfeeding
• Incarceration
• Participation in another intervention study
• Severe anemia defined as hemoglobin <9.0 g/dl