Role of Stem Cells, Platelet Rich Plasma in Treatment of Scars

Role of Stem Cells, Platelet Rich Plasma and Combination of Them in Treatment of Scars

The Objectives of this randomized controlled trial aiming to establishing a protocol of post scar revision care and to Study the effect of PRP and/or Adipose derived Mesenchymal Stem cell injection in improvement of atrophic scar after scar revision.

Forty patients with atrophic scar since one to five years including 25 males and 15 females with ages ranging from ten to 35 years with main age of 22.68 will be divided into four groups each included ten patients. One group will be treated with scar revision only (control group or group I), 2nd group will be injected with PRP after scar revision, 3rd group will be injected with ADSCs after scar revision and the 4th group will be injected with a combination of PRP and ADSCs after scar revision. All groups were assisted pre-operative and six months post-operative. Complications, Scar width, Vancouver scar scale (VSS), surgeon assessment scar scale and patient assessment scar scale will be considered the outcome measurements.

Inclusion Criteria:

• Patient with atrophic scar.
• Age group: 5 years up to 35 years.
• No previous medications, surgeries or laser therapy.

Exclusion Criteria:

• Patient with hypertrophic or pigmented scar.
• Patient with any blood disease.
• Patients with lipodystrophy.