Impact of Branched-chain Amino Acids in the Development of Insulin Resistance

Branched-Chain Amino Acid Dietary Reduction Under Weight Maintainance in Overweight Patients With Type 2 Diabetes

The purpose of this study is to clarify the role of the branched-chain amino acids in the development of Insulin resistance in patients with diabetes

The proposed project aims to elucidate the role of the BCAA in the development of insulin resistance and type 2 diabetes. The project tests the hypothesis that a diet induced decrease of BCAAs concentrations alter the metabolic mechanisms involved in the control insulin resistance and diabetes progression.

The specific aims are to elucidate the effect of the diet induced decrease of BCAAs concentrations on (I) peripheral and hepatic insulin sensitivity (II) ectopic fat distribution (III) energy metabolism (IV) metabolic and inflammatory status

Inclusion Criteria:

• Diabetes type 2
• Non smokers
• Untrained
• Willingness to adhere to a diet intervention

Exclusion Criteria:

• Chronic disease
• Pregnancy
• Cancer
• Antibiotic therapy
• Drug/alcohol abuse
• Competitive athletes