Effect of Antigens or Therapeutic Agents on in Vitro Human Intestinal Organoids

Establishment of Small Intestinal Human Organoids to Check the Influence of Nutrient Antigens or Therapeutic Agents

The study evaluates the effect of nutrient antigens or therapeutic agents on human small intestinal organoids.

Small intestinal biopsies will be taken to establish human intestinal organoids in vitro. The organoids will be propagated and various antigens will be checked for their effects on proliferation, production of inflammatory components or signal cascade.

Inclusion Criteria:

• patients with gastrointestinal disorders and therapeutical indication of gastroduodenoscopy or coloscopy
• healthy controls for preventive medical check-up

Exclusion Criteria:

• pregnant women