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The study evaluates the effect of nutrient antigens or therapeutic agents on human small intestinal organoids.
Small intestinal biopsies will be taken to establish human intestinal organoids in vitro. The organoids will be propagated and various antigens will be checked for their effects on proliferation, production of inflammatory components or signal cascade.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy controls | healthy controls | ||
| patients with allergy | patients with Food intolerances or Food allergy | ||
| gastrointestinal disorders | patients with inflammatory bowel disease, irritable bowel disease, gluten sensitivity, short bowel syndrome |
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| Measure | Description | Time Frame |
|---|---|---|
| Determination of proliferation, apoptosis, histology, and cytokine Expression before and after Antigen provocation of organoids with gluten peptides, nutritional Antigens, Glucagon like peptide antagonist, or Tumor nekrose factor antagonists | Determination of effects on organoids after antigen Stimulation with ELISA, histochemistry, RNA or proteome analysis | baseline vs 24h vs 48h vs 72h |
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Inclusion Criteria:
Exclusion Criteria:
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-Patients with patients with Food intolerances, Food allergy, intestinal disorders, glutensensitivity, healthy controls who underwent a gastroduodenoscopy or coloscopy for therapeutical intervention or screening
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg | Erlangen | 91052 | Germany |
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| ID | Term |
|---|---|
| D007410 | Intestinal Diseases |
| ID | Term |
|---|---|
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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