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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL134808 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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Hypertension is the major risk factor for cardiovascular and cerebrovascular diseases worldwide. The escalating prevalence of inadequate sleep now parallels that of hypertension. Observational and experimental evidence favoring a causal relation between insufficient sleep and hypertension are particularly compelling - sleeping 6 hours or less per night is associated with a 20-32% higher probability of incident hypertension. Since sleep curtailment is largely voluntary, sleep deficiency may be corrected and the detrimental health consequences potentially reversed.
In this study the investigators aim to investigate the effects of 8 weeks of sleep enhancement/extension vs health education in prehypertensive and stage 1 hypertensive subjects who report habitual short sleep (≤6.5 hours/night).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sleep Enhancement | Experimental |
| |
| Health Education | Placebo Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep Enhancement | Behavioral | This regimen combines education and behavioral skills to enable prolonging sleep in chronically sleep deprived subjects so as to better meet participant's sleep needs. This intervention emphasizes plain language communication of cognitive behavioral therapy strategies for initiating and maintaining health behavior change, primarily through using brief action plans (time-limited, personally relevant, behavioral goal setting with confidence), and collaborative problem-solving. Coaching will be provided to modify daily routines and adhere to sleep hygiene practices to allow for extended time in bed. |
| Measure | Description | Time Frame |
|---|---|---|
| change in 48-hour mean arterial pressure | changes in ambulatory measure of blood pressure | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| changes in 48-hour heart rate | changes in 24-hour heart rate | 8 weeks |
| changes in baroreflex sensitivity | changes in baroreflex sensitivity |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Virend Somers, MD, PhD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States |
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| ID | Term |
|---|---|
| D058246 | Prehypertension |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Health Education | Behavioral | This is a placebo/attention control condition. Participants will receive health education based on NIH information. Number, duration, and frequency of sessions will be identical to those administered to the intervention group. |
|
| 8 weeks |
| changes in endothelial function | changes in endothelial function | 8 weeks |
| changes in renin | changes in renin | 8 weeks |
| changes in angiotensin peptides | changes in angiotensin peptides | 8 weeks |
| changes in aldosterone | changes in aldosterone | 8 weeks |
| changes in insulin sensitivity | changes in insulin sensitivity | 8 weeks |
| changes in cortisol | changes in cortisol | 8 weeks |
| changes in body fat | changes in body fat | 8 weeks |
| changes in catecholamines | changes in catecholamines | 8 weeks |