Efficacy and Safety of Melatonin and Clonazepam for IRBD

Efficacy and Safety of Melatonin and Rivotril Treatment for Idiopathic Rapid Eye Movement Sleep Disorder: Prospective Randomized Study.

This study aimed to evaluate influence of melatonin or clonazepam treatment on symptom and polysomnographic parameters in patients with idiopathic REM sleep behavior disorder.

This study is open-label parallel trial with 4 weeks treatment with slow-release melatonin (Circadin) or with clonazepam (Rivotril).

Polysomnography, symptom diary and questionnaire (Clinical Global Impression, RBDQ-HK, PSQI, ESS, SSS, ISI, BDI-II) will be performed before and after 4 weeks of each medications.

Inclusion Criteria:

• REM sleep behavior disorder (ICSD-3 criteria)

Exclusion Criteria:

• Neurological disorder including epilepsy or stroke
• History of psychiatric illness
• Neurodegenerative disease including dementia or parkinsonism.
• Medication affecting sleep within 1 month
• Intake of melatonin or clonazepam within 1 week.
• Unable to complete questionnaires