Biomarkers of resistance to neoadjuvant chemotherapy in locally advanced breast cancer

Identification and evaluation of biomarkers of resistance to neoadjuvant chemotherapy and establishment of preclinical models of resistance in locally advanced breast cancer

Inclusion Criteria:

• proven invasive breast adenocarcinoma (cytology and / or biopsy).

  • locally advanced stage (tumor size greater than 2 cm).
  • neoadjuvant chemotherapy indication validated RCP
  • Patient eligible for neoadjuvant chemotherapy.
  • Performance Index according to WHO or less 1.
  • Patient aged 18 years and older.
  • Being affiliated to a social security scheme or an equivalent scheme of social protection
  • Obtaining signed informed consent, and that before any specific prequalification testing.

Exclusion Criteria:

• presence of metastatic disease at diagnosis.

  • Breast Cancer inflammatory.
  • rare histologic subtypes (non ductal lobular and not).
  • Other cancer (except basal cell skin carcinoma and cancer of the cervix in situ adequately treated and curative) treated in the previous 5 years.
  • Patient pregnant or nursing or of childbearing age without effective contraception.
  • Breast cancer in men.
  • legal incapacity or limited legal capacity. medical or psychological conditions allowing the subject to complete the study or to sign the consent (art. L.1121-6, L.1121-7, L.1211-8, L1211-9).