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The purpose of this study is to determine how using auditory cues of a metronome and music at various frequencies impacts the gait mechanics in people with Parkinson's disease when walking over ground and on a treadmill.
The investigators will enroll a total of 40 participants: 30 subjects with a diagnosis of Parkinson's disease (10 in Stage 1, 10 in Stage 2, and 10 in Stage 3) and 10 unimpaired subjects.
Participants will complete 7 different treadmill walking conditions and overground walking conditions while the investigators measure step length, cadence, gait speed, and variability of movement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Walking: Treadmill then Overground | Experimental | Walking while receiving auditory cueing intervals from a metronome and music. Testing performed using metronome normal, metronome slow, and metronome fast speed settings as well as music normal, music slow, and music fast tempos. Subjects will also walk with no auditory cueing. |
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| Walking: Overground, then Treadmill | Experimental | Walking while receiving auditory cueing intervals from a metronome and music. Testing performed using metronome normal, metronome slow, and metronome fast speed settings as well as music normal, music slow, and music fast tempos. Subjects will also walk with no auditory cueing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metronome Normal | Other | Steps are timed with the beat of the metronome set to the subject's cadence |
|
| Measure | Description | Time Frame |
|---|---|---|
| Step Length | The length of each step taken while walking on a treadmill or overground. It is the anteroposterior distance from one foot to the other at heel strike measured during walking under each condition. | The entire duration of each condition, approximately 2 minutes each. |
| Measure | Description | Time Frame |
|---|---|---|
| Cadence | The number of steps taken per minute measured while walking on a treadmill or overground under each condition. | The entire duration of each condition, approximately 2 minutes each. |
| Gait speed |
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10 unimpaired controls and 30 subjects with Parkinson's Disease (described in detail below - see inclusion/exclusion criteria). The 30 subjects with Parkinson's Disease will be assigned into 3 groups (10 with H&Y Stage 1, 10 with H&Y Stage 2, and 10 with H&Y Stage 3).
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Guneet Chawla | University of North Carolina, Chapel Hill | Principal Investigator |
| Michael Lewek, PT, PhD | University of North Carolina, Chapel Hill | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Metronome Slow | Other | Steps are timed with the beat of the metronome set to 85% of the subject's cadence |
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| Metronome Fast | Other | Steps are timed with the beat of the metronome set to 115% of the subject's cadence |
|
| Music Normal | Other | Steps are timed with the beat of the music by a rhythm consistent with the subject's cadence |
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| Music Slow | Other | Steps are timed with the beat of the music by a rhythm consistent with 85% of the subject's cadence |
|
| Music Fast | Other | Steps are timed with the beat of the music by a rhythm consistent with 115% of the subject's cadence |
|
| No Auditory cueing | Other | Steps are not timed with any auditory cue. |
|
The distance covered in a measured period of time (meters per second) while walking overground under each condition.
| The entire duration of each condition, approximately 2 minutes each. |
| Movement variability | The coefficient of variation of spatiotemporal measures (step timing and step length) while walking overground and on a treadmill under each condition. | The entire duration of each condition, approximately 2 minutes each. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |