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the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.
Atherosclerosis is a major cause of ischemic stroke and a significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaques. Several studies have reported racial differences in the severity and distribution of carotid atherosclerosis. In the United States and Western communities, Extra-cranial carotid artery disease was estimated to be responsible for 20-30% of strokes. Little is known about the prevalence and distribution of carotid disease among the populations in the developing countries.
Vascular duplex ultrasound is a useful, cheap and available diagnostic tool for assessing cranial vascular disease. Duplex ultrasound can be highly reliable with proper technique, without the risk of radiation in other imaging modalities, is well tolerated by all patients including those who are claustrophobic in MRI machines, and has much less risks compared to conventional angiography studies.
Although vascular duplex has been used for years yet there is little researches had been done on normal population in the developing countries to collect results and compare it to the parameters that was collected and reviewed in the western developed populations.
The parameters that would be used in this study include both the data collected by static and dynamic duplex scan which are the intimal-medial thickness, the vessels' diameter, peak flow velocity and peak flow volume both systolic and diastolic for either extra- or intra-cranial vessels.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vascular duplex ultrasound imaging | Radiation | Duplex ultrasound is a non-invasive evaluation of blood flow through cranial arteries and veins. |
| Measure | Description | Time Frame |
|---|---|---|
| Normal intimal-medial thickness measured in millimeter | Estimation of the intimal-medial thickness for cranial vessels. | 24 months |
| Normal vessels' diameter measured in millimeter | Estimation of the vessels' diameter | 24 months |
| Normal peak flow velocity measured in cm/sec | peak flow velocity both systolic and diastolic for cranial vessels | 24 months |
| Normal indices | pulsatility index and resistance index for cranial vessels | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Early detection of subjects at risk of atherosclerosis | detection of subjects with early atherosclerotic changes for further management | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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Egyptian population
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tarek A Rageh, PHD | Contact | +0201223849203 | Tarek_rageh@hotmail.com | |
| Khaled O Abosheira, PHD | Contact | +0201003012229 |
| Name | Affiliation | Role |
|---|---|---|
| Mostafa H Ghazally, MBChB | Assiut University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15470212 | Background | Yadav JS, Wholey MH, Kuntz RE, Fayad P, Katzen BT, Mishkel GJ, Bajwa TK, Whitlow P, Strickman NE, Jaff MR, Popma JJ, Snead DB, Cutlip DE, Firth BG, Ouriel K; Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy Investigators. Protected carotid-artery stenting versus endarterectomy in high-risk patients. N Engl J Med. 2004 Oct 7;351(15):1493-501. doi: 10.1056/NEJMoa040127. | |
| 11692017 |
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| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D002340 | Carotid Artery Diseases |
| D058226 | Plaque, Atherosclerotic |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Background |
| Grau AJ, Weimar C, Buggle F, Heinrich A, Goertler M, Neumaier S, Glahn J, Brandt T, Hacke W, Diener HC. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke. 2001 Nov;32(11):2559-66. doi: 10.1161/hs1101.098524. |
| 1561677 | Background | Timsit SG, Sacco RL, Mohr JP, Foulkes MA, Tatemichi TK, Wolf PA, Price TR, Hier DB. Early clinical differentiation of cerebral infarction from severe atherosclerotic stenosis and cardioembolism. Stroke. 1992 Apr;23(4):486-91. doi: 10.1161/01.str.23.4.486. |
| 24094043 | Background | Svicero DJ, Doiche DP, Mamprim MJ, Heckler MC, Amorim RM. Ultrasound evaluation of common carotid artery blood flow in the Labrador retriever. BMC Vet Res. 2013 Oct 7;9:195. doi: 10.1186/1746-6148-9-195. |
| D002561 |
| Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |