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| Name | Class |
|---|---|
| Northwest Women's and Children's Hospital, Xi'an, Shaanxi | OTHER |
| Chengdu Women's and Children's Central Hospital | OTHER |
| Shenzhen Maternity & Child Healthcare Hospital | OTHER |
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This study hypothesizes that early-onset neonatal Infections are related to premature rupture of membrane (PROM) and that early intervention can improve the prognosis of newborns. The objective of this study is to analyze the correlation between PROM and early-onset neonatal infections and to assess the prognosis of newborns. A cohort study is designed to implement the study. The subjects of study group are pregnant women who are diagnosed as PROM or chorioamnionitis and whose gestational age is ≥ 24 weeks. The subjects of control group are pregnant women without PROM and chorioamnionitis. Control group and research group are paired at 1: 1 ratio. The main contents of the study include three aspects. (1) The correlation between PROM and chorioamnionitis. (2) The correlation between PROM and early-onset neonatal infections. (3) The pathogenesis of intrauterine infection and neonatal infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group | pregnant women who are diagnosed as PROM or chorioamnionitis and whose gestational age is ≥ 24 weeks | ||
| control group | pregnant women without PROM and chorioamnionitis |
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| Measure | Description | Time Frame |
|---|---|---|
| the incidence of early-onset neonatal infections | The incidence of early-onset neonatal infections will be compared between study group and control group. | 7 days after birth |
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Inclusion Criteria:
Exclusion Criteria:
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The pregnant women who are hospitalized to delivery in the collaborator hospitals.
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| Name | Affiliation | Role |
|---|---|---|
| Xing Li | Bayi Children's Hospital Affiliated to PLA Army General Hospital, China | Principal Investigator |
| Shaodong Hua | Bayi Children's Hospital Affiliated to PLA Army General Hospital, China | Principal Investigator |
| Jie Cui | Bayi Children's Hospital Affiliated to PLA Army General Hospital, China | Principal Investigator |
| Lei Li | Bayi Children's Hospital Affiliated to PLA Army General Hospital, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chengdu Women's and Children's Central Hospital | Chengdu | China | ||||
| Second Hospital of Jilin University |
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| ID | Term |
|---|---|
| D005322 | Fetal Membranes, Premature Rupture |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Nanjing Maternity and Child Health Care Hospital |
| OTHER |
| Shenzhen Bao'an Maternal and Child Health Hospital | OTHER |
| Second Hospital of Jilin University | OTHER |
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| Jilin City |
| China |
| Nanjing Maternity and Child Health Care Hospital | Nanjing | China |
| Shenzhen Bao'an Maternal and Child Health Hospital | Shenzhen | China |
| Shenzhen Maternity & Child Healthcare Hospital | Shenzhen | China |
| Northwest Women's and Children's Hospital | Xi'an | China |