Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Edwards Lifesciences | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Prospective cohort study to test the hypothesis that patients identified with severe aortic stenosis are under-diagnosed and under-treated. Such patients shall be identified by auscultation or target echocardiography during flu vaccination. The hypothesis is that this will increase detection of aortic stenosis in the community.
The design plans for two study phases:
In each phase, the patient will be identified by auscultation and target echocardiography. Management and onward referral will be at the clinical discretion of the GP. Results of clinical review, investigation, follow-up and management will be recorded at 3 months from that date.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| newly identified aortic stenosis | Patients identified on auscultation or target echocardiography with aortic stenosis. Consecutive patients per centre with no limit to numbers. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| prevalence of aortic stenosis | Determination of the prevalence of aortic stenosis detected on screening performed during flu vaccination. | From date of examination until follow-up after three months |
| comparison of detection rate of aortic stenosis | Comparison of detection rates of aortic stenosis using target auscultation vs detection by target 2D echocardiography. | From date of examination until follow-up after three months |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of qualitative estimation of calcium burden on 2D echocardiography as a marker of AS severity | Method evaluation | three months |
| Calculation of costs in screening with auscultation versus target 2DE in screening for AS to inform future cost-efficacy studies of screening for AS. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients identified on auscultation or target echocardiography with aortic stenosis. Consecutive patients per centre with no limit to numbers.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Richard Steeds, MD | Queen Elizabeth Hospital, Birmingham, UK | Principal Investigator |
| Peter Bramlage, MD | IPPMed UK Ltd | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Whaddon Medical Center | Milton Keynes | Buckinghamshire | MK3 7QU | United Kingdom | ||
| Swanswell Medical Centre |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Cost evaluation |
| three months |
| Birmingham |
| B27 7AL |
| United Kingdom |
| D014694 |
| Ventricular Outflow Obstruction |