The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy. The radio- and chemosensitive effect of an additional hyperthermia might improve the clinical outcome.

Inclusion Criteria:

• Histological confirmed carcinoma of the Cervix
• FIGO-Stage IIB-IVA; earlier stages when inoperable or according to patient's wish
• clinical M0; except: involvement of para-aortic lymph nodes
• Age ≥ 18 years
• ECOG ≤ 2
• Informed consent of the patient

Exclusion Criteria:

• Pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy
• Cardiac Pacemaker
• Myocardial infarction within the past 12 months
• Congestive heart failure
• Complete bundle branch block
• New York Heart Association (NYHA) class III or IV heart disease
• Disease that would preclude chemoradiation or deep regional hyperthermia
• Metal implants (length > 2cm or dense clusters of marker clips in the pelvis)
• Active or therapy-resistent bladder infections
• Pre-existing or concommitant immunodeficiency Syndrome
• Pregnant or lactating women
• Patients not willing to use effective contraception during and up to 6 months after therapy