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The aim of this study is to investigate whether an individualized determination of energy requirements using indirect calorimetry instead of a formula-based approach leads to an optimized nutritional support and as a consequence to an optimized nutritional status of the critically ill, mechanically ventilated patients measured by the phase angle.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Indirect Calorimetry | Experimental | The energy need is being determined by using indirect calorimetry and if necessary, optimized by parenteral, enteral and additive parenteral nutrition. |
|
| Standard Care | No Intervention | This group receives nutrition supply according to the hospital routine ("standard care") |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indirect Calorimetry | Other | Energy need is being determined using indirect Calorimetry |
|
| Measure | Description | Time Frame |
|---|---|---|
| Phase angle (PhA) | The primary endpoint is the change of the phase angle during the stay in the intensive care unit (ICU). A mean difference of 5% is considered as relevant. | PhA was measured between one and 90 days (during ICU stay) |
| Measure | Description | Time Frame |
|---|---|---|
| Nitrogen Balance | Difference between intervention and control group between hospital admission and discharge. | Nitrogen Balance was measured between one and 90 days (during ICU stay) |
| Extracellular to body cell mass ratio (ECM/BCM - Ratio) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephan C Bischoff | University of Hohenheim, 70599 Stuttgart, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hohenheim | Stuttgart | 70599 | Germany |
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D002153 | Calorimetry, Indirect |
| ID | Term |
|---|---|
| D002151 | Calorimetry |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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Difference between intervention and control group between hospital admission and discharge.
| ECM/BCM-Ratio was measured between one and 90 days (during ICU stay) |
| Length of hospital stay in days | Difference between intervention and control group between hospital admission and discharge. | Length of hospital stay was measured between one and 180 days |
| Length of stay in intensive care unit (ICU) in days | Difference between intervention and control group between hospital admission and discharge. | Length of ICU stay was measured between one and 90 days |