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An endoscopic third ventriculostomy is considered to be successful in idiopathic normal pressure hydrocephalus (iNPH) in some literature reports, but there is a lack of high quality data. The aim of the present study is to compare the treatment options of iNPH (Endoscopic third ventriculostomy versus ventriculo-peritoneal shunt) in a randomized, controlled, multicenter study.
The traditional treatment for communicating hydrocephalus is a ventriculo-peritoneal shunt insertion and the endoscopic third ventriculostomy (ETV) is reserved for patients with obstructive hydrocephalus. However, in the last decade several reports highlighted an success of an ETV in communicating hydrocephalus as well. Thus, the aim of the present study is to compare ventriculo-peritoneal shunting against ETV in patients with an idiopathic normal pressure hydrocephalus, an subset of communicating hydrocephalus, in a randomized, controlled multicenter study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| endoscopic third ventriculostomy | Experimental | endoscopic third ventriculostomy for the treatment of iNPH |
|
| ventricular peritoneal shunt | Active Comparator | Insertion of a ventriculo-peritoneal Shunt for the treatment of iNPH |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endoscopic Third Ventriculostomy | Procedure | patients receive an endoscopic third ventriculotomy as surgical procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Kiefer Index | Improvment of at least 2 points | 1 year |
| Recovery Index | Improvment of at least 2 points | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medicine Göttingen | Not yet recruiting | Göttingen | Germany |
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| Ventriculo-Peritoneal Shunting | Procedure | patients receive an ventriculo-peritoneal shunt as surgical procedure |
|
| University Medicine Greifswald | Recruiting | Greifswald | 17489 | Germany |
|
| Klinikum Neubrandenburg | Recruiting | Neubrandenburg | Germany |
|
| ID | Term |
|---|---|
| D006850 | Hydrocephalus, Normal Pressure |
| D006849 | Hydrocephalus |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D014696 | Ventriculostomy |
| ID | Term |
|---|---|
| D002557 | Cerebrospinal Fluid Shunts |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D019635 | Neurosurgical Procedures |
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