Transcatheter Mitral Valve Replacement With the Medtronic... | NCT03242642 | Trialant

Transcatheter Mitral Valve Replacement With the Medtronic... | NCT03242642 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Primary Cohort- TMVR	Experimental	Treatment of mitral regurgitation with the Medtronic Transcatheter Mitral Valve Replacement System (TMVR)	Device: Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Mitral Annular Calcification -TMVR	Experimental	Treatment of mitral regurgitation with the Medtronic Transcatheter Mitral Valve Replacement System (TMVR)	Device: Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)	Device	mitral valve replacement	Mitral Annular Calcification -TMVR Primary Cohort- TMVR

Outcomes Module

Secondary Outcomes

Measure	Description	Time Frame
All-cause mortality, disabling stroke, acute kidney injury, prolonged ventilation, deep wound infection, reoperation or reintervention, and major bleeding	Composite	30 days or hospital discharge (whichever is later)
Degree of mitral regurgitation

Contacts/Locations Module

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
41251714	Derived	Tang GHL, Rajagopal V, Sorajja P, Bajwa T, Gooley R, Walton A, Modine T, Ng MK, Williams MR, Zajarias A, Hildick-Smith D, Tchetche D, Spargias K, Rajani R, Bapat VN, De Backer O, Blackman D, McCarthy P, Laine M, Jain R, Martin R, Thaden JJ, Marka NA, Mack M, Adams DH, Leon MB, Reardon MJ. Five-year outcomes of the early-generation Intrepid transapical transcatheter mitral valve replacement system. EuroIntervention. 2026 Feb 2;22(3):e172-e182. doi: 10.4244/EIJ-D-25-01133.