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| Name | Class |
|---|---|
| Mahidol Oxford Tropical Medicine Research Unit | OTHER |
| Economic and Social Research Council, United Kingdom | OTHER |
| Mae Fah Luang University | OTHER |
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The investigators will conduct two rural surveys in Thailand and Lao PDR to improve the understanding of antibiotic-related health behaviour among the general population. One survey will capture a cross-section of health behaviours that is representative for the rural population in Chiang Rai (Thailand) and Salavan (Lao PDR), the other survey will create a two round village-level panel data set to study the evolution of health behaviours in the context of public engagement activities. The investigators will also collect complementary data about village-level infrastructure through observational check-lists, and collect secondary data on patient load from primary care units catering to their survey villages. As part of the questionnaire testing process, the investigators will conduct (and collect as primary data) cognitive interviews to improve the survey tool, to interpret their data, and to justify their methodological choices.
The investigators will collect two data sets each in Lao PDR and Thailand: the first contains district-level representative health behaviour of approx. 2,400 adults across 30 rural communities per country (4,800 in total; representing rural populations of approx. 1-2 million adults); the second is a complete social network census of approx. 1600 adults each in three rural communities per country (approx. 4,800 in total). Within the sampled villages, the investigators will complete checklists about existing formal and informal healthcare facilities and gather patient load data from primary care units catering to the respective villages. As part of the questionnaire testing process, the investigators will conduct (and collect as primary data) cognitive interviews to improve the survey tool, to interpret our data, and to justify our methodological choices. The investigators will carry out the district-level village survey in one round, and the village-level social network censuses in two rounds. Between the two village social network censuses, the investigators will engage in public engagement activities in the selected villages (focused on antibiotic use) and re-survey all adults in the three villages per country two to three months later.
Objectives:
The primary objective is to improve the understanding of patients' antibiotic-related behaviour to support creative thinking about targeted and unconventional antimicrobial resistance (AMR) interventions in low- and middle-income countries (LMICs).
The investigators strive to achieve this primary objective by informing three research questions in Chiang Rai (Thailand) and Salavan (Lao PDR):
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| district-level representative rural survey | Approximately 4,800 adults in 60 villages across Thailand and Lao PDR to study health and antimicrobial resistance (AMR)-related behaviour in breadth. |
| |
| village-level social network census | Approximately 4,800 adults across 6 villages in rural Thailand and Lao PDR that are exposed to AMR awareness activities to study health behaviour within social networks. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational study of behaviour | Behavioral | As a general population survey, our study does not involve a control group. Please note that the investigators do not interview patients; we involve only healthy members of the general public who consider themselves fit to be interviewed. |
| Measure | Description | Time Frame |
|---|---|---|
| General population and villagelevel data on antibiotic access and use within individuals' healthcare-seeking pathways | To improve the understanding of patients' antibiotic-related behaviour to support creative thinking about targeted and unconventional antimicrobial resistance (AMR) interventions in low- and middle-income countries (LMICs). | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for November 2017 to April 2018 |
| Measure | Description | Time Frame |
|---|---|---|
| Indicators of economic, social, and spatial marginalisation | To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for November 2017 to April 2018 |
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Inclusion Criteria:
Exclusion Criteria:
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Groups included in this study comprise adults (aged 18 years and above) in rural Lao PDR (Salavan) and in rural Thailand (Chiang Rai). As a general population survey, the study does not involve a control group. Please note that the investigators do not interview patients; the investigators involve only healthy members of the general public who consider themselves fit to be interviewed.
Sampling method:
1.3-stage stratified random cluster sampling 2.Complete census of all adults among 3 purposively sampled villages per country
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| Name | Affiliation | Role |
|---|---|---|
| Marco Haenssgen, Dr. | Mahidol Oxford Tropical Medicine Unit | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit | Vientiane | Laos | ||||
| Chiangrai Clinical research Unit |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33298471 | Derived | Haenssgen MJ, Charoenboon N, Xayavong T, Althaus T. Precarity and clinical determinants of healthcare-seeking behaviour and antibiotic use in rural Laos and Thailand. BMJ Glob Health. 2020 Dec;5(12):e003779. doi: 10.1136/bmjgh-2020-003779. | |
| 31434769 | Derived | Haenssgen MJ, Charoenboon N, Zanello G, Mayxay M, Reed-Tsochas F, Lubell Y, Wertheim H, Lienert J, Xayavong T, Khine Zaw Y, Thepkhamkong A, Sithongdeng N, Khamsoukthavong N, Phanthavong C, Boualaiseng S, Vongsavang S, Wibunjak K, Chai-In P, Thavethanutthanawin P, Althaus T, Greer RC, Nedsuwan S, Wangrangsimakul T, Limmathurotsakul D, Elliott E, Ariana P. Antibiotic knowledge, attitudes and practices: new insights from cross-sectional rural health behaviour surveys in low-income and middle-income South-East Asia. BMJ Open. 2019 Aug 20;9(8):e028224. doi: 10.1136/bmjopen-2018-028224. |
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Data collected for this study will be de-identified and may be shared with other groups of researchers in accordance with the current MORU Data Sharing Policy provided the respondents consented to data sharing. Specifically, the investigators aim to make their survey data publicly available on the UK Data Service and other local and regional data sharing platforms like the Thai data service in order to enable other researchers the opportunity to study antibiotic-related behaviour in Thailand and Lao PDR.
Data access on the UK Data Service will be free and without a case-by-case assessment, provided repository users agree to the terms and conditions of the UK Data Service and to cite the data sources in all publications emerging from the data, using suggested citations. Data preparation and documentation process will commence in May 2018; deposition will take place within three months of project completion. The data sets will also be utilised as training resources in the context of global health education and social network analysis
Direct access will be granted to authorised representatives from the sponsor or host institution for monitoring and/or audit of the study to ensure compliance with regulations. Following data entry and validation, we will deposit the de-identified quantitative survey data with the UK Data Service for open access. Data access will be free and without a case-by-case assessment, provided repository users agree to the terms and conditions of the UK Data Service and to cite the data sources in all publications emerging from the data, using suggested citations (see Section 10.6 on Data Sharing for further details). The qualitative data from the cognitive interviews will not be made open access or shared with other researchers.
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|
| Access to formal and informal medical treatment |
To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways. |
| The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Access to prescription and over-the-counter medicines including antibiotics | To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Degree of technology use during the healthcare seeking process | To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Awareness about "rational" antibiotic use | To understand the manifestations and determinants of problematic antibiotic use in patients' healthcare-seeking pathways. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Typologies of desirable and undesirable healthcare practices with respect to antibiotic use | To understand whether people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Social network structures in rural communities | To understand whether people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Demand fluctuations for healthcare services over time within rural communities | To understand whether people's exposure to antibiotic awareness activities entail changed behaviours that diffuse or dissipate within a network of competing healthcare practices. | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Proxy indicators that predict problematic antibiotic use in the general population | To identify less data-intensive indicators to detect problematic contexts of antibiotic use | The study is expected to take place from January 2017 to October 2018, with data collection scheduled for April 2018. |
| Chiang Rai |
| Chiangrai |
| 50007 |
| Thailand |
| 29629190 | Derived | Haenssgen MJ, Charoenboon N, Zanello G, Mayxay M, Reed-Tsochas F, Jones COH, Kosaikanont R, Praphattong P, Manohan P, Lubell Y, Newton PN, Keomany S, Wertheim HFL, Lienert J, Xayavong T, Warapikuptanun P, Khine Zaw Y, U-Thong P, Benjaroon P, Sangkham N, Wibunjak K, Chai-In P, Chailert S, Thavethanutthanawin P, Promsutt K, Thepkhamkong A, Sithongdeng N, Keovilayvanh M, Khamsoukthavong N, Phanthasomchit P, Phanthavong C, Boualaiseng S, Vongsavang S, Greer RC, Althaus T, Nedsuwan S, Intralawan D, Wangrangsimakul T, Limmathurotsakul D, Ariana P. Antibiotics and activity spaces: protocol of an exploratory study of behaviour, marginalisation and knowledge diffusion. BMJ Glob Health. 2018 Mar 28;3(2):e000621. doi: 10.1136/bmjgh-2017-000621. eCollection 2018. |