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Overweight/obese Chinese and prediabetes will be recruited and divided into three age-matched groups including high intensity exercise, moderate intensity exercise, and non-exercise groups. The exercise program will consist of three sessions per week over the course of 12 weeks, under the supervision of our in-house exercise specialists and physiologists. The effects of exercise on glucose and lipid profiles, insulin sensitivity and adiposity will be evaluated.
60 Chinese men aged between 21 and 60 years old with overweight/obesity (25 kg/m2 \
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intensity intervention | Experimental | Exercise intervention at 70 to 80% of estimated heart rate maximum for 12 weeks. |
|
| Moderate intensity intervention | Experimental | Exercise intervention at 50 to 70% of estimated heart rate maximum for 12 weeks. |
|
| non-exercise group | No Intervention | Participants will not receive any type of exercise training. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise intervention | Behavioral | A period of 12-week exercise intervention under the supervision of exercise specialists will be conducted. |
|
| Measure | Description | Time Frame |
|---|---|---|
| change of fasting glucose | fasting glucose level | change from baseline fasting glucose level at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| alterations of gut microbiome | advanced metagenomics to identify gut microbiota species altered by exercise training | before, 4 weeks and 12 weeks after exercise training |
| rate of non-responsiveness in the alleviation of insulin resistance to exercise intervention |
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Inclusion Criteria:
- overweight/obese Chinese man (25 kg/m2\
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| Name | Affiliation | Role |
|---|---|---|
| Aimin Xu | Department of Medicine, The University of Hong Kong | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medicine | Hong Kong | Hong Kong |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39473051 | Derived | Wang Y, Chen J, Ni Y, Liu Y, Gao X, Tse MA, Panagiotou G, Xu A. Exercise-changed gut mycobiome as a potential contributor to metabolic benefits in diabetes prevention: an integrative multi-omics study. Gut Microbes. 2024 Jan-Dec;16(1):2416928. doi: 10.1080/19490976.2024.2416928. Epub 2024 Oct 29. | |
| 36134579 | Derived |
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| ID | Term |
|---|---|
| D011236 | Prediabetic State |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Participants in the exercise arms are further classified into responders or non-responsders, depending on whether they could demonstrate a decrease of insulin resistance index (HOMA-IR) greater than 2-fold technical error, which is a threshold for true physiological adaptation. HOMA-IR is calculated using homeostasis model assessment methods, defined as fasting insulin (μU/mL)×fasting glucose (mmol/L)/22.5. |
| before and after 12 weeks after exercise training |
| Jin L, Geng L, Ying L, Shu L, Ye K, Yang R, Liu Y, Wang Y, Cai Y, Jiang X, Wang Q, Yan X, Liao B, Liu J, Duan F, Sweeney G, Woo CWH, Wang Y, Xia Z, Lian Q, Xu A. FGF21-Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity. Circulation. 2022 Nov 15;146(20):1537-1557. doi: 10.1161/CIRCULATIONAHA.122.059631. Epub 2022 Sep 22. |
| 31786155 | Derived | Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A. Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention. Cell Metab. 2020 Jan 7;31(1):77-91.e5. doi: 10.1016/j.cmet.2019.11.001. Epub 2019 Nov 27. |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |