Endoscopic Mucosal Resection and Cellular Matrix

A Randomized Study of Biologic Scaffolds And Esophageal Healing Following Endoscopic Resection

This study is being done to test the usefulness of extracellular matrix (ECM) a thin sheet placed over the site after endoscopic mucosal resection to promote healing of the esophagus.

Inclusion Criteria

• Able to provide consent
• Scheduled for standard of care endoscopy that may require initial EMR evaluation of esophageal lesions
• Histological evidence of intestinal metaplasia with dysplasia or intramucosal carcinoma

Exclusion Criteria

• Pregnant women
• Prior esophageal EMR or ESD in the same region
• Anyone unable to provide informed consent
• Medical co-morbidities precluding EGD evaluation
• History of chemoradiotherapy to the neck/esophagus
• Unable to stop anticoagulation therapy (non-steroid anti-inflammatory medications are permissible)