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Painful cutaneous electrical stimulation (PCES) and corresponding evoked potentials led to a significant pain relief and decrease of evoked potentials and has been used to analyze conditioned pain modulation (CPM). However, it is unknown whether the pain relief results from habituation to the repeated painful electric stimulation. We compared the effects of CPM and habituation on PCES-induced pain and PCES-evoked potentials and analyzed whether increased attention by a random change of electric intensities amplifies the habituation effects.
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| Measure | Description | Time Frame |
|---|---|---|
| pain relief | pain intensity of painful cutaneous electrical stimulation on a numeric rating scale (NRS 0-100) | during the measurement |
| N1P1-amplitude | Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV | during the measurement |
| Measure | Description | Time Frame |
|---|---|---|
| N1-latency | Latency of the peak N1 of painful cutaneous electrical stimulation evoked potentials in msec | during the measurement |
| P0N1-amplitude | Amplitudes of painful cutaneous electrical stimulation evoked potentials in µV |
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Inclusion Criteria:
Exclusion Criteria:
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healthy subjects
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| Name | Affiliation | Role |
|---|---|---|
| Christoph Maier, Prof Dr med | University clinic Bergmannsheil Bochum gGmbH, Department of pain medicine | Principal Investigator |
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| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| during the measurement |