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This is a non-interventional study,aim to observe the safety and efficiency of different treatment regimen for peritoneal metastasis of Stage IV gastric cancer in the real world
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chemotherapy Group | chemotherapy treatment(S-1 and Oxaliplatin) for patients until disease progress |
| |
| Chemotherapy plus HIPEC Group | Hyperthermic Intraperitoneal chemoperfusion(HIPEC)with Paclitaxel more than 2 cycles and plus chemotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| S-1 | Drug | 40-60mg/m^2 bid, days 1-14, oral,every 3 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| PFS: Progression Free Survival | time from enrollment to disease progression or death | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| OS:overall survival | time from enrollment to death | 3 years |
| Safety | measured by recording the subjects' Adverse Events according to CTCAE 4.03 |
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Inclusion Criteria:
Exclusion Criteria:
Total bilirubin >2 pper limit of normal range (ULN); ALT / AST > 2.5 upper limit of normal range (ULN); serum creatinine > 1.5 mg/dL, and Ccr > 60 ml/min (estimated by Cockcroft-Gault formulation);
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Patients with histologically confirmed gastric cancer or gastroesophageal junction adenocarcinoma, stage IV with peritoneal metastasis
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| Name | Affiliation | Role |
|---|---|---|
| Kuan Wang | Harbin Medical University Cancer Hospital,Gastrointestinal Surgical department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Harbin Medical University Cancer Hospital | Harbin | Heilongjiang | 150081 | China |
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| ID | Term |
|---|---|
| C079198 | S 1 (combination) |
| D000077150 | Oxaliplatin |
| D000084262 | Hyperthermic Intraperitoneal Chemotherapy |
| D017239 | Paclitaxel |
| ID | Term |
|---|---|
| D056831 | Coordination Complexes |
| D009930 | Organic Chemicals |
| D017024 | Chemotherapy, Adjuvant |
| D003131 | Combined Modality Therapy |
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| oxaliplatin | Drug | 100mg/m^2 days 1,intravenous infusion, every 3 weeks. |
|
| Hyperthermic Intraperitoneal | Device | hyperthermic intraperitoneal chemoperfusion |
|
| Paclitaxel | Drug | intraperitoneal perfusion |
|
| 3 years |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
| D006979 | Hyperthermia, Induced |
| D043823 | Taxoids |
| D043822 | Cyclodecanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D004224 | Diterpenes |
| D013729 | Terpenes |