Ocular chemical burn is one of the causes of vision loss in China, and there are no satisfactory treatment. Human umbilical cord mesenchymal stem cells(UC-MSCs) have the biological characteristics of self-renewal, immune regulation, multidirectional differentiation and tissue repair. Our preliminary research showed that in corneal alkali injury rabbits, the UC-MSCs can accelerated the cornea repair, inhibited angiogenesis. The aim of this study is to access the efficacy and safety of UC-MSCs in the treatment of corneal burn in human.

Inclusion Criteria:

• must be ocular burns including chemically burned or the thermally burned;
• the subjects are willing to accept this research, and promise to coordinate with the researchers during the follow up period;
• the subjects should abide by the laws and rules of the study.

Exclusion Criteria:

• the visual acuity is blind in any of the eye;
• have corneal perforation or have the corneal perforation tendency;
• have been accepted surgery on eyeball after trauma;
• IOP>=25 mmHg even after antiglaucoma;
• have the history of other corneal disease or surgery;
• have the history of radiotherapy or surgery in the eyeball;
• associated with corneal ulcer or endoophthalmitis;
• uncontrolled hypertension(>=150/95 mmHg);
• abnormal liver and renal function;
• the pregnant women.