Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury

Biochemical and Reno-protective Effects of Remote Ischemic Pre-conditioning on Contrast-induced Acute Kidney Injury

This a prospective, double-blind, sham-controlled, randomized clinical trial to study the effects of remote ischemic preconditioning on acute kidney injury, vascular and renal biomarkers in patients with non-ST elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention.

The BRICK study is a prospective, double-blind, sham-controlled, randomized clinical trial in patients with non-ST elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention who are at high risk for acute kidney injury. The study will investigate the effects of remote ischemic preconditioning before cardiac catheterization on rate of acute kidney injury and novel biomarkers of renal injury/protection within 48hrs of coronary angiography and/or percutaneous coronary intervention.

Inclusion Criteria:

• Patient with non-ST elevation myocardial infarction or unstable angina
• Referral for cardiac catheterization and percutaneous coronary intervention
• Contrast-induced acute kidney injury risk score of ≥11

Exclusion Criteria:

• Inability to give informed consent
• unstable blood pressure (systolic blood pressure > 200 or <90 mmHg)
• History of allergy to contrast media
• Peripheral vascular disease of upper limb
• Renal disease requiring dialysis
• Placement of arteriovenous fistula and arteriovenous graft