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This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous total anesthesia (TIVA) over inhaled anesthesia for this procedures.
IL-6, TNFα and cortisol will be measure at the beginning of the cardiovascular surgery and 20 minutes after the cardiovascular bypass ends to calculate the difference between them and compare if there is any statistical difference between the proinflammatory markers with the two anesthesia techniques.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Inhaled anesthesia (Sevoflurane) | Patients undergoing cardiovascular surgery with inhaled anesthesia with sevoflurane. |
| |
| Total Intravenous Anesthesia (Propofol) | Patients undergoing cardiovascular surgery with total intravenous anesthesia with propofol. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Propofol anesthesia Dose: 4-6mg/kg/h |
|
| Measure | Description | Time Frame |
|---|---|---|
| IL-6 | IL-6 will be compared between the groups. | The difference between IL-6 at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass |
| Measure | Description | Time Frame |
|---|---|---|
| TNFα | TNFα will be compared between the groups | The difference between TNFα at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass |
| Cortisol | Cortisol will be compared between the groups |
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Inclusion Criteria:
Scheduled for cardiovascular surgery American Society of Anaesthesiologists (ASA) physical status classification II-IV BMI < 25 HbA1c < 7%
Exclusion Criteria:
Diabetic patients Known allergy to propofol
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Patients scheduled for cardiovascular surgery
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| Name | Affiliation | Role |
|---|---|---|
| Ana Gallardo, PhD | Instituto Mexicano del Seguroa Social | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de cardiología | Mexico City | Mexico City | 06720 | Mexico |
The plan is not decided yet.
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Sevoflurane | Drug | Inhaled anesthesia with sevoflurane. Dose: 1-2.5 Minimum Alveolar Concentration(MAC) |
|
|
| The difference between cortisol at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |