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The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.
This study will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Patients | Active Comparator | All healthy volunteers will complete the healthy volunteer form, MRI safety screening form, and the Montreal Cognitive Assessment (MOCA). |
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| PMD/PNES patients | Active Comparator | PMD and PNES subjects will be referred by the treating |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sham TMS3 stimulation | Device | half of the subjects will receive sham stimulation first |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in signal intensity measured using of tDCS | as a result of altering cerebral perfusion in response to neurophysiologic stimulation | 30 Minutes |
| Changes in signal intensity measured during EEG recording | as a result of altering cerebral perfusion in response to neurophysiologic stimulation | 3 Hours |
| Changes in signal intensity measured during MEG | as a result of altering cerebral perfusion in response to neurophysiologic stimulation | 3 Hours |
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Inclusion Criteria:
(Healthy Controls)
(Patients with PMD or PNES):
Exclusion Criteria:
PMD and PNES Patients
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nalini Jeet | Contact | (212) 263-0228 | Nalini.Jeet@nyulangone.org |
| Name | Affiliation | Role |
|---|---|---|
| Biyu He, MD | NYU Langone Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New York University School of Medicine | Recruiting | New York | New York | 10016 | United States |
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| ID | Term |
|---|---|
| D012640 | Seizures |
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| rTMS of left or right angular gyrus (AG) or frontal cortex (FC) | Device | Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study. |
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| Anodal tDCS of left or right AG or FC | Device | Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study. |
|
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| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |